Chemically-tagged Mitsunobu Reagents for Use in Solution-phase Chemical Library Synthesis

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 1999 Jan 5

PMID 9873546

Citations 4

Authors

G W STARKEY

J J Parlow

D L Flynn

Affiliations

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Abstract

A general method for high-throughput product purification of Mitsunobu reactions is described. Tagged phosphine and azodicarboxylate reagents are used to synthesize individual library members in solution-phase. Workup and purification are easily accomplished by post-reaction sequestration of the tagged reagents and reagent byproducts by a complementary functionalized ion exchange resin. The reagents are utilized in a 3 step library synthesis.

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