New Synthetic Inhibitors of Microtubule Depolymerization

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 1999 Jan 1

PMID 9871773

Citations 6

Authors

U Klar

H Graf

O Schenk

B Rohr

H Schulz

Affiliations

Soon will be listed here.

Abstract

A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.

Citing Articles

Norbornene and Related Structures as Scaffolds in the Search for New Cancer Treatments.

Calvo-Martin G, Plano D, Martinez-Saez N, Aydillo C, Moreno E, Espuelas S Pharmaceuticals (Basel). 2022; 15(12).

PMID: 36558915 PMC: 9780886. DOI: 10.3390/ph15121465.

Taccalonolide C-6 Analogues, Including Paclitaxel Hybrids, Demonstrate Improved Microtubule Polymerizing Activities.

Risinger A, Hastings S, Du L J Nat Prod. 2021; 84(6):1799-1805.

PMID: 34110822 PMC: 8656239. DOI: 10.1021/acs.jnatprod.1c00211.

The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.

Kingston D, Snyder J Acc Chem Res. 2014; 47(8):2682-91.

PMID: 25052294 PMC: 4139185. DOI: 10.1021/ar500203h.

Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.

Correa P, Miranda R, Duarte L, Silva G, Filho S, Okuma A Pathog Glob Health. 2012; 106(2):107-12.

PMID: 22943546 PMC: 4001496. DOI: 10.1179/2047773212Y.0000000002.

Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation.

Zhao J, Bane S, Snyder J, Hu H, Mukherjee K, Slebodnick C Bioorg Med Chem. 2011; 19(24):7664-78.

PMID: 22071526 PMC: 3225578. DOI: 10.1016/j.bmc.2011.10.010.