Transcription Factor CREM Coordinates the Timing of Hepatocyte Proliferation in the Regenerating Liver

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 1998 Dec 16

PMID 9851970

Citations 22

Authors

G Servillo

M A Della Fazia

P Sassone-Corsi

Affiliations

Soon will be listed here.

Abstract

The liver regenerates upon partial hepatectomy (PH) as terminally differentiated hepatocytes undergo a tremendous proliferative process. CREM gene expression is powerfully induced during liver regeneration. We show that cell proliferation is significantly reduced upon PH in CREM-/- mice. There is a reduction in DNA synthesis, in the number of mitosis and of phosphorylated histone H3-positive cells. The post-PH proliferation peak is delayed by 10 hr, indicating an altered hepatocyte cell cycle. Expression of cyclins A, B, D1, E, and cdc2, of c-fos and tyrosine aminotransferase is deregulated. CREM mutation results in delayed S-phase entry, impairing the synchronization of proliferation.

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