Postantibiotic Effect and Postantibiotic Sub-MIC Effect of Quinupristin-dalfopristin Against Gram-positive and -negative Organisms

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1998 Oct 31

PMID 9797249

Citations 10

Authors

G A Pankuch

M R Jacobs

P C Appelbaum

Affiliations

Soon will be listed here.

Abstract

Quinupristin-dalfopristin produced postantibiotic effects (PAEs) and postantibiotic sub-MIC effects of >2 h against 18 gram-positive cocci. Mean pneumococcal and staphylococcal PAEs were 2.8 and 4.7 h, respectively, with shorter PAEs for constitutively than inducibly macrolide-resistant staphylococci. Mean PAEs for vancomycin-susceptible and -resistant Enterococcus faecium were 8.5 and 2.6 h, respectively.

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