Synthesis of Eel-calcitonin and (asu1,7)-eel-calcitonin: Contribution of the Disulfide Bond to the Hormonal Activity

Overview

Journal Experientia

Specialty Science

Date 1976 Sep 15

PMID 971732

Citations 21

Authors

T Morikawa

E Munekata

S Sakakibara

T Noda

M Otani

Affiliations

Soon will be listed here.

Abstract

Eel-calcitonin and its [asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.

Citing Articles

Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases.

Sonne N, Karsdal M, Henriksen K Mol Metab. 2020; 46:101109.

PMID: 33166741 PMC: 8085567. DOI: 10.1016/j.molmet.2020.101109.

Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations.

Xie J, Guo J, Kanwal Z, Wu M, Lv X, Ibrahim N Int J Endocrinol. 2020; 2020:3236828.

PMID: 32963524 PMC: 7501564. DOI: 10.1155/2020/3236828.

Efficacy and safety of elcatonin in postmenopausal women with osteoporosis: a systematic review with network meta-analysis of randomized clinical trials.

Chen W, Lin E, Kang Y Osteoporos Int. 2019; 30(9):1723-1732.

PMID: 31041475 DOI: 10.1007/s00198-019-04997-6.

Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures.

Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, Ito M J Bone Miner Metab. 2016; 35(5):544-553.

PMID: 27830386 DOI: 10.1007/s00774-016-0791-6.

Improvement of Quality of Life (QOL) in Osteoporotic Patients by Elcatonin Treatment: A Trial Taking the Participants' Preference into Account.

Yoh K, Uzawa T, Orito T, Tanaka K Jpn Clin Med. 2013; 3:9-14.

PMID: 23946680 PMC: 3738553. DOI: 10.4137/JCM.S8291.

References

ODor R, Parkes C, Copp D . Amino acid composition of salmon calcitonin. Can J Biochem. 1969; 47(8):823-5. DOI: 10.1139/o69-128. View

Niall H, Keutmann H, Copp D, Potts Jr J . Amino acid sequence of salmon ultimobranchial calcitonin. Proc Natl Acad Sci U S A. 1969; 64(2):771-8. PMC: 223410. DOI: 10.1073/pnas.64.2.771. View

Rittel W, Maier R, Brugger M, Kamber B, RINIKER B, Sieber P . [Structure-activity relationship of human calcitonin. III. Biological activity of synthetic analogues with shortened or terminally modified peptide chains (author's transl)]. Experientia. 1976; 32(2):246-8. DOI: 10.1007/BF01937791. View

Sakakibara S, Shimonishi Y . A new method for releasing oxytocin from fully-protected nona-peptides using anhydrous hydrogen fluoride. Bull Chem Soc Jpn. 1965; 38(8):1412-3. DOI: 10.1246/bcsj.38.1412. View

Keutmann H, Parsons J, Potts Jr J, SCHLUETER R . Isolation and chemical properties of two calcitonins from salmon ultimobranchial glands. J Biol Chem. 1970; 245(6):1491-6. View