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[Structure-activity Relationship of Human Calcitonin. III. Biological Activity of Synthetic Analogues with Shortened or Terminally Modified Peptide Chains (author's Transl)]

Overview
Journal Experientia
Specialty Science
Date 1976 Feb 15
PMID 1269626
Citations 9
Authors
W Rittel
R Maier
M Brugger
B Kamber
B RINIKER
P Sieber
Affiliations
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Abstract

Assays of 8 synthetic analogues of human calcitonin in rats showed that their hypocalcaemic activity was drastically reduced by deletion of the C-terminal amide group, chain-shortening or opening of the disulphide ring, but unaffected or enhanced by modification of the N-terminal amino group.

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References
1.
Neher R, RINIKER B, Rittel W, Zuber H . [Human calcitonin. Structure of calcitonin M and D]. Helv Chim Acta. 1968; 51(8):1900-5. DOI: 10.1002/hlca.19680510811. View
2.
Sieber P, RINIKER B, Brugger M, Kamber B, Rittel W . [Human calcitonin. VI. Synthesis of calcitonin M]. Helv Chim Acta. 1970; 53(8):2135-50. DOI: 10.1002/hlca.19700530826. View
3.
RINIKER B, Brugger M, Kamber B, Sieber P, Rittel W . [Thyrocalcitonin. IV. The total synthesis of alpha-thyrocalcitonin]. Helv Chim Acta. 1969; 52(4):1058-73. DOI: 10.1002/hlca.19690520420. View
4.
Kumar M, Slack E, Edwards A, Soliman H, BAGHDIANTZ A, FOSTER G . A biological assay for calcitonin. J Endocrinol. 1965; 33(3):469-75. DOI: 10.1677/joe.0.0330469. View
5.
Byfield P, Clark M, Turner K, FOSTER G, MacIntyre I . Immunochemical studies on human calcitonin M leading to information on the shape of the molecule. Biochem J. 1972; 127(1):199-206. PMC: 1178574. DOI: 10.1042/bj1270199. View