Composite Glandular-neuroendocrine Carcinoma of the Hilar Bile Duct: Report of a Case

Overview

Journal Surg Today

Specialty General Surgery

Date 1998 Aug 11

PMID 9697272

Citations 8

Authors

J Yamamoto

Y Abe

K Nishihara

F Katsumoto

S Takeda

R Abe

S Toyoshima

Affiliations

Soon will be listed here.

Abstract

We report herein an unusual case of a composite glandular-neuroendocrine carcinoma of the hilar bile duct. A 71-year-old Japanese woman was admitted to our hospital suffering from general fatigue, progressive jaundice, and a high fever. Computed tomography and angiography findings revealed a solid hypervascular mass in the hepatic hilus. Thus, a subsegmentectomy of the liver (S4, S5) and bile duct resection with lymph node dissection were performed. A tumor measuring 6.0 x 3.0 cm was found to be located in the bile duct of the hepatic hilus. Histologically, the tumor was composed of well-differentiated adenocarcinoma and small cell neuroendocrine carcinoma cells, with a histological transition between the two components. Grimelius' method revealed the presence of diffuse positive tumor cells in neuroendocrine carcinoma. The neuroendocrine tumor cells were also diffusely immunoreactive to chromogranin A. To the best of our knowledge, only 22 previous cases of composite glandular-neuroendocrine carcinoma in the biliary tract have been reported; however, this is the first case report of a clearly composite tumor of the hilar bile duct.

Citing Articles

Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma: A case report and review of literature.

Chen F, Li W, Mo J, Chen M, Wang S, Yang S World J Gastrointest Surg. 2024; 16(5):1449-1460.

PMID: 38817298 PMC: 11135321. DOI: 10.4240/wjgs.v16.i5.1449.

Neuroendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review.

Zhang L, Wan D, Bao L, Chen Q, Xie H, Xu S Medicine (Baltimore). 2018; 97(29):e11487.

PMID: 30024526 PMC: 6086531. DOI: 10.1097/MD.0000000000011487.

A long-term recurrence-free survival of a patient with the mixed adeno-neuroendocrine bile duct carcinoma: A case report and review of the literature.

Izumo W, Higuchi R, Yazawa T, Uemura S, Matsunaga Y, Shiihara M Int J Surg Case Rep. 2017; 39:43-50.

PMID: 28806619 PMC: 5554986. DOI: 10.1016/j.ijscr.2017.07.052.

Large-cell neuroendocrine carcinoma of the common bile duct: a case report and a review of literature.

Murakami M, Katayama K, Kato S, Fujimoto D, Morikawa M, Koneri K Surg Case Rep. 2016; 2(1):141.

PMID: 27888490 PMC: 5124016. DOI: 10.1186/s40792-016-0269-8.

A case report of primary neuroendocrine carcinoma of the perihilar bile duct.

Kihara Y, Yokomizo H, Urata T, Nagamine M, Hirata T BMC Surg. 2015; 15:125.

PMID: 26652845 PMC: 4676104. DOI: 10.1186/s12893-015-0116-z.

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