Endocrine Cell Carcinoma (carcinoid) of the Gallbladder

Overview

Journal Am J Surg Pathol

Date 1989 Apr 1

PMID 2648878

Citations 17

Authors

M Yamamoto

S Nakajo

N Miyoshi

S Nakai

E Tahara

Affiliations

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Abstract

We report two cases of endocrine cell carcinoma of the gallbladder associated with adenocarcinoma. The patients were women with numerous gallstones. Histologically, the tumors consisted of adenocarcinoma and endocrine cell carcinoma. An apparent transition was noted between the two types. Tumor cells of both the endocrine cell carcinoma and the adenocarcinoma were argyrophilic. In one case the tumor was surrounded by metaplastic mucosa; in the other case, it was surrounded by dysplastic and metaplastic mucosa. The nonneoplastic mucosae also contained argyrophil cells in varying number. These findings suggest that endocrine cell carcinoma of the gallbladder is derived from metaplastic epithelium of the gallbladder.

Citing Articles

Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review.

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Synchronous but separate neuroendocrine tumor and high-grade dysplasia/adenoma of the gall bladder: A case report.

Hsiao T, Wu C, Tseng H, Chen J World J Clin Cases. 2022; 10(7):2322-2329.

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Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome.

Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich D, Koo D Langenbecks Arch Surg. 2021; 407(1):197-206.

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A case of neuroendocrine carcinoma in the hepatic hilar lymph nodes concomitant with an adenocarcinoma of the gallbladder.

Okada H, Uchida Y, Matsuzaki N, Goto T, Nishimura S, Kurita A World J Surg Oncol. 2016; 14(1):284.

PMID: 27842605 PMC: 5109806. DOI: 10.1186/s12957-016-1039-6.

Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.

La Rosa S, Sessa F, Uccella S Endocr Pathol. 2016; 27(4):284-311.

PMID: 27169712 DOI: 10.1007/s12022-016-9432-9.