LC: Clinical Syndrome in Different Primaries

Overview

Journal J Neurooncol

Publisher Springer

Date 1998 Aug 8

PMID 9696359

Citations 12

Authors

G Wolfgang

D Marcus

S Ulrike

Affiliations

Soon will be listed here.

Abstract

Leptomeningeal carcinomatosis (LC) occurs in solid tumors like breast, lung carcinoma and melanoma, rarely sarcoma and in leukemia and lymphoma. Clinical symptoms of LC often present with differential diagnostic problems. The most common presentation are multiple neuraxis syndromes which for didactic reasons are classically considered as central nervous system (CNS), spinal (SP) or cranial nerve (CN) symptoms and signs and appear isolated or more frequently in combinations. It is generally agreed that signs are usually more prominent than symptoms. Only few series focus on monolocular presentation at clinical manifestation. This overview describes the clinical symptoms and signs in patients with LC, the concept of multiple neuraxis lesions, CNS, CN and SP signs and symptoms. Also the problem of new symptoms and signs in patients treated with antineoplastic chemotherapy and radiation is addressed. The study is based on own results and a survey of the present literature.

Citing Articles

Blindness due to leptomeningeal carcinomatosis as an initial manifestation of recurrent acute lymphoblastic leukemia.

Huang Y, Wang C, Jou J Taiwan J Ophthalmol. 2020; 9(4):288-291.

PMID: 31942438 PMC: 6947751. DOI: 10.4103/tjo.tjo_107_17.

Meningeal metastasis of a malignant peritoneal mesothelioma: A case report and literature review.

Jiang Y, Mei Z, Cao H, Li S, Xu H, Qiu H Cancer Biol Ther. 2019; 20(12):1409-1415.

PMID: 31411522 PMC: 6804805. DOI: 10.1080/15384047.2019.1647053.

Leptomeningeal metastasis as initial manifestation of signet ring colorectal adenocarcinoma: a case report with review of literature.

Assi R, Hamieh L, Mukherji D, Haydar A, Temraz S, El-Dika I J Gastrointest Oncol. 2015; 6(6):E89-E101.

PMID: 26697206 PMC: 4671853. DOI: 10.3978/j.issn.2078-6891.2015.087.

Asynchronous leptomeningeal carcinomatosis from pancreatic cancer: a case report and review of the literature.

Hong C, Kurt H, Elder J Clin J Gastroenterol. 2015; 7(5):434-40.

PMID: 26184025 DOI: 10.1007/s12328-014-0518-y.

Carcinomatous meningitis in non-small cell lung cancer: Palliation with intrathecal treatment.

Kumar D, Noronha V, Joshi A, Jain H, Prabhash K Indian J Med Paediatr Oncol. 2014; 35(1):75-8.

PMID: 25006289 PMC: 4080668. DOI: 10.4103/0971-5851.133726.

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