Leptomeningeal Metastasis As Initial Manifestation of Signet Ring Colorectal Adenocarcinoma: a Case Report with Review of Literature

Overview

Journal J Gastrointest Oncol

Date 2015 Dec 24

PMID 26697206

Citations 8

Authors

Rita Assi

Lana Hamieh

Deborah Mukherji

Ali Haydar

Sally Temraz

Imane El-Dika

Ali Shamseddine

Affiliations

Soon will be listed here.

Abstract

Leptomeningeal carcinomatosis (LMC) is an exceedingly rare event especially as a first manifestation of an occult primary colorectal cancer and even when there is a known history of malignancy. Sensorineural hearing loss is by itself an unusual isolated presentation of LMC with unsolved pathophysiology in this setting. In this paper, we report such a case and review the literature for similar cases, focusing on postulated mechanisms of spread. In view of the poor prognosis they carry, we highly recommend that physicians be aware of the risk of rare metastasis from colorectal adenocarcinoma in order to establish an early confirmative diagnosis.

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