TGF-beta Signaling and Cancer: Structural and Functional Consequences of Mutations in Smads

Overview

Journal Mol Med Today

Specialties General Medicine
Molecular Biology

Date 1998 Jul 29

PMID 9679244

Citations 38

Authors

A Hata

Y Shi

J Massague

Affiliations

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Abstract

Transforming growth factor-beta (TGF-beta) and related cytokines control the development and homeostasis of many tissues by regulating the expression of genes that determine cell phenotype. Recent progress has elucidated the way in which members of the TGF-beta family initiate their signal through transmembrane receptors and transmit it to target genes via the Smad family of signal-transducing proteins. This review describes TGF-beta signaling pathways as currently understood and mutations of the genes that encode Smads that disrupt the function of these proteins and cause various forms of cancer.

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Aberrations in SMAD family of genes among HNSCC patients.

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Tumor: Stroma Interaction and Cancer.

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