Going the Distance: a Current View of Enhancer Action

Overview

Journal Science

Specialty Science

Date 1998 Jul 25

PMID 9679020

Citations 336

Authors

E M Blackwood

J T Kadonaga

Affiliations

Soon will be listed here.

Abstract

In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional enhancers are discrete DNA elements that contain specific sequence motifs with which DNA-binding proteins interact and transmit molecular signals to genes. Here, current models regarding the role of enhancers in the regulation of transcription by RNA polymerase II are presented.

Citing Articles

The insulator has sub-elements with different insulating and long-range pairing properties.

Fujioka M, Ke W, Schedl P, Jaynes J bioRxiv. 2025; .

PMID: 39896478 PMC: 11785010. DOI: 10.1101/2024.02.01.578481.

The chromosome folding problem and how cells solve it.

Dekker J, Mirny L Cell. 2024; 187(23):6424-6450.

PMID: 39547207 PMC: 11569382. DOI: 10.1016/j.cell.2024.10.026.

Translation of genome-wide association study: from genomic signals to biological insights.

Bruner W, Grant S Front Genet. 2024; 15:1375481.

PMID: 39421299 PMC: 11484060. DOI: 10.3389/fgene.2024.1375481.

Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedside.

Xu L, Yao S, Ding Y, Xie M, Feng D, Sha P J Transl Med. 2024; 22(1):866.

PMID: 39334366 PMC: 11429861. DOI: 10.1186/s12967-024-05661-2.

Impact of putatively beneficial genomic loci on gene expression in little brown bats (, Le Conte, 1831) affected by white-nose syndrome.

Kwait R, Pinsky M, Gignoux-Wolfsohn S, Eskew E, Kerwin K, Maslo B Evol Appl. 2024; 17(9):e13748.

PMID: 39310794 PMC: 11413065. DOI: 10.1111/eva.13748.