Structure and Function of TSPY, the Y-chromosome Gene Coding for the "testis-specific Protein"

Overview

Journal Cytogenet Cell Genet

Publisher Karger

Specialty Genetics

Date 1998 Jul 25

PMID 9678360

Citations 16

Authors

T Vogel

J Schmidtke

Affiliations

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Abstract

The TSPY genes are arranged in clusters on the Y chromosome of many mammalian species. TSPY is believed to function in early spermatogenesis and is a candidate for GBY, the putative gonadoblastoma-inducing gene on the Y. The TSPY family forms part of a superfamily, TTSN, with autosomal representatives, highly conserved in mammals and beyond.

Citing Articles

Testis-Specific Protein Y-Encoded (TSPY) Is Required for Male Early Embryo Development in .

Rho N, Mogas T, King W, Favetta L Int J Mol Sci. 2023; 24(4).

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Assessment of the vaginal residence time of biomarkers of semen exposure.

Thurman A, Jacot T, Melendez J, Kimble T, Snead M, Jamshidi R Contraception. 2016; 94(5):512-520.

PMID: 27259675 PMC: 5075505. DOI: 10.1016/j.contraception.2016.05.012.

An Exceptional Gene: Evolution of the TSPY Gene Family in Humans and Other Great Apes.

Xue Y, Tyler-Smith C Genes (Basel). 2014; 2(1):36-47.

PMID: 24710137 PMC: 3924835. DOI: 10.3390/genes2010036.

Transgenic Mouse Studies to Understand the Regulation, Expression and Function of the Testis-Specific Protein Y-Encoded (TSPY) Gene.

Schubert S, Schmidtke J Genes (Basel). 2014; 1(2):244-62.

PMID: 24710044 PMC: 3954093. DOI: 10.3390/genes1020244.

Testicular cancer: biology and biomarkers.

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