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Activity of Azlocillin and Mezlocillin Against Gram-negative Organisms: Comparison with Other Penicillins

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1978 Apr 1
PMID 96726
Citations 26
Authors
R Wise
A P Gillett
J M Andrews
K A Bedford
Affiliations
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Abstract

The activities of azlocillin and mezlocillin were compared with those of carbenicillin, ticarcillin, and pirbenicillin against a wide range of gram-negative organisms. The two new drugs were considerably more active than carbenicillin against Klebsiella species and Escherichia coli. Carbenicillin was twice as active against Proteus mirabilis as mezlocillin and four times as active as azlocillin. Against Pseudomonas aeruginosa, azlocillin was eight times as active as carbenicillin. Azlocillin and mezlocillin were twice as active as carbenicillin against Bacteroides fragilis, and these drugs showed a high degree of activity against Haemophilus influenzae and Neisseria gonorrhoeae.

Citing Articles

[Azlocillin--a new anti-pseudomonas penicillin. A review of the literature and pharmacokinetic studies].

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PMID: 7152688 DOI: 10.1007/BF01640668.

Elimination of azlocillin in patients with biliary t-tube drainage.

Gundert-Remy U, Weber E Eur J Clin Pharmacol. 1982; 22(5):435-9.

PMID: 7117356 DOI: 10.1007/BF00542549.

Ticarcillin: a review of its pharmacological properties and therapeutic efficacy.

Brogden R, Heel R, Speight T, Avery G Drugs. 1980; 20(5):325-52.

PMID: 7002527 DOI: 10.2165/00003495-198020050-00001.

Activity and synergy of ureido penicillins and aminoglycosides against Pseudomonas aeruginosa.

Hoogkamp-Korstanje J, Westerdaal N Infection. 1982; 10 Suppl 3:S257-61.

PMID: 6818158 DOI: 10.1007/BF01640684.

The in vitro activity of beta-lactam antibiotics against gentamicin and/or carbenicillin-resistant Pseudomonas aeruginosa strains.

Aisa M, Omenaca M, Bergua C Infection. 1982; 10 Suppl 3:S244-8.

PMID: 6818157 DOI: 10.1007/BF01640682.

References
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