Quantitative Assessment of Regional Myocardial Blood Flow with Thallium-201 and SPECT

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 1998 Jul 21

PMID 9669586

Citations 25

Authors

H Iida

S Eberl

Affiliations

Soon will be listed here.

Abstract

Thallium-201 has been used extensively as a myocardial perfusion agent and to assess myocardial viability. Unlike other 99mTc-labeled agents such as 99mTc-sestamibi and 99mTc-tetrofosmine, the regional concentration of 201Tl varies with time, and its kinetics make it a potential candidate for estimating absolute physiologic parameters with kinetic model analysis. This article outlines a strategy for quantitative assessment of regional myocardial blood flow in man using 201Tl and dynamic single photon emission computed tomography (SPECT). Quantitatively accurate SPECT images that are proportional to the true radioactivity distribution are prerequisites for model-based kinetic analysis. Our technique for quantitative SPECT includes ordered-subset maximum likelihood-expectation maximization (ML-EM) reconstruction with transmission data-based attenuation correction and transmission-dependent convolution subtraction scatter correction. A three-compartment model was found to reproduce the observed regional time-activity curves well, and dog experiments demonstrated that influx rate constant (K1) values estimated from the dynamic SPECT data correlated well with absolute myocardial blood flow determined by in vitro microspheres for a physiologically wide range of flows. Several possible strategies for simplifying the study procedures, without compromising accuracy, are also presented, which should make absolute quantitation of regional myocardial blood flow feasible using 201Tl and a conventional SPECT camera in a clinical setting.

Citing Articles

First validation of myocardial flow reserve assessed by dynamic Tc-sestamibi CZT-SPECT camera: head to head comparison with O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study.

Agostini D, Roule V, Nganoa C, Roth N, Baavour R, Parienti J Eur J Nucl Med Mol Imaging. 2018; 45(7):1079-1090.

PMID: 29497801 PMC: 5953996. DOI: 10.1007/s00259-018-3958-7.

Quantitative Assessment of Coronary Microvascular Function: Dynamic Single-Photon Emission Computed Tomography, Positron Emission Tomography, Ultrasound, Computed Tomography, and Magnetic Resonance Imaging.

Feher A, Sinusas A Circ Cardiovasc Imaging. 2017; 10(8).

PMID: 28794138 PMC: 5678979. DOI: 10.1161/CIRCIMAGING.117.006427.

A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT.

Sciammarella M, Shrestha U, Seo Y, Gullberg G, Botvinick E J Nucl Cardiol. 2017; 26(3):763-771.

PMID: 28776314 PMC: 5920770. DOI: 10.1007/s12350-017-1016-7.

Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls.

Buchert R, Kluge A, Tossici-Bolt L, Dickson J, Bronzel M, Lange C Eur J Nucl Med Mol Imaging. 2016; 43(7):1323-36.

PMID: 26816194 DOI: 10.1007/s00259-016-3309-5.

Myocardial blood flow quantification with SPECT and conventional tracers: a critical appraisal.

Nekolla S, Rischpler C, Nakajima K J Nucl Cardiol. 2014; 21(6):1089-91.

PMID: 25280762 DOI: 10.1007/s12350-014-9996-z.

References

Okada R, Leppo J, Boucher C, Pohost G . Myocardial kinetics of thallium-201 after dipyridamole infusion in normal canine myocardium and in myocardium distal to a stenosis. J Clin Invest. 1982; 69(1):199-209. PMC: 371183. DOI: 10.1172/jci110431. View

Ito H, Iida H, Bloomfield P, Murakami M, Inugami A, Kanno I . Rapid calculation of regional cerebral blood flow and distribution volume using iodine-123-iodoamphetamine and dynamic SPECT. J Nucl Med. 1995; 36(4):531-6. View

Meikle S, Hutton B, Bailey D . A transmission-dependent method for scatter correction in SPECT. J Nucl Med. 1994; 35(2):360-7. View

LLAURADO J, Madden J, Meade R, Smith G . Distribution of thallium-201 injected into rats following stress: imaging, organ to plasma uptake ratios, and myocardial kinetics. J Nucl Med. 1978; 19(2):172-7. View

Yokoi T, Kanno I, Iida H, Miura S, Uemura K . [A fast technique to estimate local cerebral blood flow and partition coefficient using dynamic PET of H(2)15O: a new approach to weighted integration method based on time integration of Kety-Schmidt equation]. Kaku Igaku. 1990; 27(3):273-7. View

Hudson H, Larkin R . Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging. 1994; 13(4):601-9. DOI: 10.1109/42.363108. View

Iida H, Miura S, Shoji Y, Ogawa T, Kado H, Narita Y . Noninvasive quantitation of cerebral blood flow using oxygen-15-water and a dual-PET system. J Nucl Med. 1998; 39(10):1789-98. View

Crone C . THE PERMEABILITY OF CAPILLARIES IN VARIOUS ORGANS AS DETERMINED BY USE OF THE 'INDICATOR DIFFUSION' METHOD. Acta Physiol Scand. 1963; 58:292-305. DOI: 10.1111/j.1748-1716.1963.tb02652.x. View

King M, Coleman M, Penney B, Glick S . Activity quantitation in SPECT: a study of prereconstruction Metz filtering and use of the scatter degradation factor. Med Phys. 1991; 18(2):184-9. DOI: 10.1118/1.596705. View

10.

Axelsson B, Msaki P, Israelsson A . Subtraction of Compton-scattered photons in single-photon emission computerized tomography. J Nucl Med. 1984; 25(4):490-4. View

11.

Iida H, Itoh H, Bloomfield P, MUNAKA M, Higano S, Murakami M . A method to quantitate cerebral blood flow using a rotating gamma camera and iodine-123 iodoamphetamine with one blood sampling. Eur J Nucl Med. 1994; 21(10):1072-84. DOI: 10.1007/BF00181062. View

12.

Nakajima K, Shuke N, Taki J, Ichihara T, Motomura N, Bunko H . A simulation of dynamic SPECT using radiopharmaceuticals with rapid clearance. J Nucl Med. 1992; 33(6):1200-6. View

13.

Bergmann S, Herrero P, Markham J, Weinheimer C, WALSH M . Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography. J Am Coll Cardiol. 1989; 14(3):639-52. DOI: 10.1016/0735-1097(89)90105-8. View

14.

Tan P, Bailey D, Meikle S, Eberl S, Fulton R, Hutton B . A scanning line source for simultaneous emission and transmission measurements in SPECT. J Nucl Med. 1993; 34(10):1752-60. View

15.

Pretorius P, King M, Pan T, de Vries D, Glick S, Byrne C . Reducing the influence of the partial volume effect on SPECT activity quantitation with 3D modelling of spatial resolution in iterative reconstruction. Phys Med Biol. 1998; 43(2):407-20. DOI: 10.1088/0031-9155/43/2/014. View

16.

Iida H, Rhodes C, De Silva R, Yamamoto Y, Araujo L, Maseri A . Myocardial tissue fraction--correction for partial volume effects and measure of tissue viability. J Nucl Med. 1991; 32(11):2169-75. View

17.

Eberl S, Anayat A, Fulton R, Hooper P, Fulham M . Evaluation of two population-based input functions for quantitative neurological FDG PET studies. Eur J Nucl Med. 1997; 24(3):299-304. DOI: 10.1007/BF01728767. View

18.

Buvat I, Rodriguez-Villafuerte M, Todd-Pokropek A, Benali H, Di Paola R . Comparative assessment of nine scatter correction methods based on spectral analysis using Monte Carlo simulations. J Nucl Med. 1995; 36(8):1476-88. View

19.

King M, Hademenos G, Glick S . A dual-photopeak window method for scatter correction. J Nucl Med. 1992; 33(4):605-12. View

20.

Iida H, Nakazawa M, Uemura K . [Quantitation of regional cerebral blood flow using 123I-IMP from a single SPECT scan and a single blood sampling--analysis on statistical error source and optimal scan time]. Kaku Igaku. 1995; 32(3):263-70. View