Evaluation of Two Population-based Input Functions for Quantitative Neurological FDG PET Studies

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1997 Mar 1

PMID 9143468

Citations 32

Authors

S Eberl

A R Anayat

R R Fulton

P K Hooper

M J Fulham

Affiliations

Soon will be listed here.

Abstract

The conventional measurement of the regional cerebral metabolic rate of glucose (rCMRGlc) with fluorodeoxyglucose (FDG) and positron emission tomography (PET) requires arterial or arterialised-venous (a-v) blood sampling at frequent intervals to obtain the plasma input function (IF). We evaluated the accuracy of rCMR-Glc measurements using population-based IFs that were calibrated with two a-v blood samples. Population-based IFs were derived from: (1) the average of a-v IFs from 26 patients (Standard IF) and (2) a published model of FDG plasma concentration (Feng IF). Values for rCMRGlc calculated from the population-based IFs were compared with values obtained with IFs derived from frequent a-v blood sampling in 20 non-diabetic and six diabetic patients. Values for rCMRGlc calculated with the different IFs were highly correlated for both patient groups (r > or = 0.992) and root mean square residuals about the regression line were less than 0.24 mg/min/100 g. The Feng IF tended to underestimate high rCMRGlc. Both population-based IFs simplify the measurement of rCMRGlc with minimal loss in accuracy and require only two a-v blood samples for calibration. The reduced blood sampling requirements markedly reduce radiation exposure to the blood sampler.

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References

Phelps M, Huang S, Hoffman E, Selin C, Sokoloff L, Kuhl D . Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol. 1979; 6(5):371-88. DOI: 10.1002/ana.410060502. View

Tamaki N, Yonekura Y, Kawamoto M, Magata Y, Sasayama S, Takahashi N . Simple quantification of regional myocardial uptake of fluorine-18-deoxyglucose in the fasting condition. J Nucl Med. 1991; 32(11):2152-7. View

Hutchins G, Holden J, Koeppe R, Halama J, Gatley S, Nickles R . Alternative approach to single-scan estimation of cerebral glucose metabolic rate using glucose analogs, with particular application to ischemia. J Cereb Blood Flow Metab. 1984; 4(1):35-40. DOI: 10.1038/jcbfm.1984.5. View

Kato A, Menon D, Diksic M, YAMAMOTO Y . Influence of the input function on the calculation of the local cerebral metabolic rate for glucose in the deoxyglucose method. J Cereb Blood Flow Metab. 1984; 4(1):41-6. DOI: 10.1038/jcbfm.1984.6. View

Huang S, Phelps M, Hoffman E, Sideris K, Selin C, Kuhl D . Noninvasive determination of local cerebral metabolic rate of glucose in man. Am J Physiol. 1980; 238(1):E69-82. DOI: 10.1152/ajpendo.1980.238.1.E69. View

Huang S, Phelps M, Hoffman E, Kuhl D . Error sensitivity of fluorodeoxyglucose method for measurement of cerebral metabolic rate of glucose. J Cereb Blood Flow Metab. 1981; 1(4):391-401. DOI: 10.1038/jcbfm.1981.43. View

Brooks R . Alternative formula for glucose utilization using labeled deoxyglucose. J Nucl Med. 1982; 23(6):538-9. View

Phillips R, Chen C, Wong D, London E . An improved method to calculate cerebral metabolic rates of glucose using PET. J Nucl Med. 1995; 36(9):1668-79. View

Iida H, Itoh H, Bloomfield P, MUNAKA M, Higano S, Murakami M . A method to quantitate cerebral blood flow using a rotating gamma camera and iodine-123 iodoamphetamine with one blood sampling. Eur J Nucl Med. 1994; 21(10):1072-84. DOI: 10.1007/BF00181062. View

10.

Iida H, Itoh H, Nakazawa M, Hatazawa J, Nishimura H, Onishi Y . Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT. J Nucl Med. 1994; 35(12):2019-30. View

11.

Feng D, Huang S, Wang X . Models for computer simulation studies of input functions for tracer kinetic modeling with positron emission tomography. Int J Biomed Comput. 1993; 32(2):95-110. DOI: 10.1016/0020-7101(93)90049-c. View

12.

Takikawa S, Dhawan V, Spetsieris P, Robeson W, Chaly T, Dahl R . Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve. Radiology. 1993; 188(1):131-6. DOI: 10.1148/radiology.188.1.8511286. View

13.

Hooper P, Meikle S, Eberl S, Fulham M . Validation of postinjection transmission measurements for attenuation correction in neurological FDG-PET studies. J Nucl Med. 1996; 37(1):128-36. View

14.

Sokoloff L, Reivich M, Kennedy C, Des Rosiers M, PATLAK C, Pettigrew K . The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977; 28(5):897-916. DOI: 10.1111/j.1471-4159.1977.tb10649.x. View

15.

Hunter G, Hamberg L, Alpert N, Choi N, Fischman A . Simplified measurement of deoxyglucose utilization rate. J Nucl Med. 1996; 37(6):950-5. View