H and M Antigens of Histoplasma Capsulatum: Preparation of Antisera and Location of These Antigens in Yeast-phase Cells

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1976 Sep 1

PMID 965099

Citations 13

Authors

J H Green

W K HARRELL

S B Gray

J E Johnson

R C Bolin

H Gross

G B Malcolm

Affiliations

Soon will be listed here.

Abstract

Antiserum has been prepared in rabbits against the H and M antigens of H. capsulatum with immunoelectrophoretic precipitin arcs used as vaccines. The antiserum is specific for H. capsulatum in the immunodiffusion test and can be used as reference serum for identifying antibodies to these antigens in sera from suspected cases histoplasmosis. We found that (1) hand m antigens are not located on the surface of yeast-phase cells and (ii) complement fixation releases the antigens reactive in the complement fixation test from yeast-phase cells.

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Localization of a yeast-phase-specific gene product to the cell wall in Histoplasma capsulatum.

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Immunobiological activity of recombinant H antigen from Histoplasma capsulatum.

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