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Isolation of a New Soluble Antigen from the Yeast Phase of Histoplasma Capsulatum

Overview
Journal Appl Microbiol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1972 Nov 1
PMID 4640739
Citations 5
Authors
M W Reeves
L Pine
L Kaufman
D McLaughlin
Affiliations
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Abstract

A method is described by which a soluble antigen was prepared from the yeast phase of Histoplasma capsulatum. This soluble preparation had a specificity greater than that of whole-cell yeast-phase antigens. In complement fixation tests with sera from human cases of histoplasmosis, blastomycosis, and coccidioidomycosis, the soluble antigen reacted in 12.1% of 141 tests with heterologous sera, whereas conventional whole-cell yeast antigens reacted in 47.3% of 91 tests with heterologous sera. The reactivities of the two types of antigens with homologous sera were essentially the same.

Citing Articles

Immunobiological activity of recombinant H antigen from Histoplasma capsulatum.

Deepe Jr G, Durose G Infect Immun. 1995; 63(8):3151-7.

PMID: 7622243 PMC: 173430. DOI: 10.1128/iai.63.8.3151-3157.1995.

Blastomyces dermatitidis antigen-induced lymphocytes reactivity in human blastomycosis.

Bradsher R, ALFORD R Infect Immun. 1981; 33(2):485-90.

PMID: 7024130 PMC: 350724. DOI: 10.1128/iai.33.2.485-490.1981.

Characterization and evaluation of a soluble antigen complex prepared from the yeast phase of Histoplasma capsulatum.

Reeves M, Pine L, Bradley G Infect Immun. 1974; 9(6):1033-44.

PMID: 4208527 PMC: 414929. DOI: 10.1128/iai.9.6.1033-1044.1974.

H and M antigens of Histoplasma capsulatum: preparation of antisera and location of these antigens in yeast-phase cells.

Green J, HARRELL W, Gray S, Johnson J, Bolin R, Gross H Infect Immun. 1976; 14(3):826-31.

PMID: 965099 PMC: 420959. DOI: 10.1128/iai.14.3.826-831.1976.

Biochemical and serological characteristics of soluble yeast phase antigens of Histoplasma capsulatum.

Malcolm G, Pine L, CHERNIAK R, MOSS C Mycopathologia. 1979; 67(1):3-16.

PMID: 450035 DOI: 10.1007/BF00436234.

References
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