Cellular Origin of Mucins of the Ocular Surface Tear Film

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 1998 Jun 23

PMID 9634890

Citations 21

Authors

I K Gipson

T Inatomi

Affiliations

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Abstract

In summary, we have demonstrated that the ocular surface epithelia express at least three mucin genes. We suggest that the gel-forming mucin MUC5AC is a major mucin forming the mucus gel of the tear film. We further suggest that MUC1 facilitates the spread of the MUC5-containing mucus on the ocular surface and, along with the mucus gel, prevents cell and debris adhesion to the ocular surface. The function of MUC4 at the ocular surface remains to be elucidated.

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Human ocular mucins: The endowed guardians of sight.

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Gene Therapy in the Anterior Eye Segment.

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Membrane-associated mucins of the human ocular surface in health and disease.

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Mucus-Penetrating Particles and the Role of Ocular Mucus as a Barrier to Micro- and Nanosuspensions.

Popov A J Ocul Pharmacol Ther. 2020; 36(6):366-375.

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