Signal Transduction Inhibitors, Hibarimicins A, B, C, D and G Produced by Microbispora. II. Structural Studies

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 1998 Jun 19

PMID 9630862

Citations 6

Authors

H Hori

Y Igarashi

T Kajiura

T FURUMAI

K Higashi

T Ishiyama

M Uramota

Y Uehara

T Oki

Affiliations

Soon will be listed here.

Abstract

The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.

Citing Articles

Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products.

Li K, Guo Z, Bai L Synth Syst Biotechnol. 2024; 9(4):701-712.

PMID: 38868608 PMC: 11167396. DOI: 10.1016/j.synbio.2024.05.012.

Synthetic studies directed toward the AB decalin common to HMP-Y1 and hibarimicinone.

Hempel J, Engers D, Sulikowski G Tetrahedron Lett. 2020; 55(13):2157-2159.

PMID: 32855575 PMC: 7449242. DOI: 10.1016/j.tetlet.2014.02.069.

A comprehensive review of glycosylated bacterial natural products.

Elshahawi S, Shaaban K, Kharel M, Thorson J Chem Soc Rev. 2015; 44(21):7591-697.

PMID: 25735878 PMC: 4560691. DOI: 10.1039/c4cs00426d.

Total syntheses of HMP-Y1, hibarimicinone, and HMP-P1.

Liau B, Milgram B, Shair M J Am Chem Soc. 2012; 134(40):16765-72.

PMID: 22970979 PMC: 3468709. DOI: 10.1021/ja307207q.

Gram-scale synthesis of the A'B'-subunit of angelmicin B.

Milgram B, Liau B, Shair M Org Lett. 2011; 13(24):6436-9.

PMID: 22084899 PMC: 3237735. DOI: 10.1021/ol202728v.