Digitoxose As Powerful Glycosyls for Building Multifarious Glycoconjugates of Natural Products and Un-natural Products

Overview

Journal Synth Syst Biotechnol

Specialty Biotechnology

Date 2024 Jun 13

PMID 38868608

Authors

Kemeng Li

Zhengyan Guo

Liping Bai

Affiliations

Soon will be listed here.

Abstract

Digitoxose, a significant 2,6-dideoxyhexose found in nature, exists in many small-molecule natural products. These digitoxose-containing natural products can be divided into steroids, macrolides, macrolactams, anthracyclines, quinones, enediynes, acyclic polyene, indoles and oligosaccharides, that exhibit antibacterial, anti-viral, antiarrhythmic, and antitumor activities respectively. As most of digitoxose-containing natural products for clinical application or preclinical tests, this review also summarizes the biosynthesis of digitoxose, and application of compound diversification by introducing sugar plasmids. It may provide a practical approach to expanding the diversity of digitoxose-containing products.

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