Modulation of Viral Immunoinflammatory Responses with Cytokine DNA Administered by Different Routes

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1998 Jun 17

PMID 9621011

Citations 9

Authors

S Chun

M Daheshia

N A KUKLIN

B T Rouse

Affiliations

Soon will be listed here.

Abstract

The efficacy of plasmid DNA encoding cytokine administered by different routes, systemic or surface exposure, was evaluated and compared for their modulating effects on subsequent lesions caused by infection with herpes simplex virus (HSV). Systemic or topical administration of both interleukin-4 (IL-4) and IL-10 DNA but not IL-2 DNA caused a long-lasting suppression of HSV-specific delayed-type hypersensitivity response. IL-4 or IL-10 DNA preadministration also modulated the expression of immunoinflammatory lesions associated with corneal infection of HSV. Suppression of ocular lesions required that the DNA be administered to the nasal mucosa or ocular surfaces and was not evident after intramuscular administration. The modulating effect of IL-10 DNA was most evident after topical ocular administration, whereas the effects of IL-4 DNA given by both routes appeared to be equal. Preexposure of IL-4 DNA, but not IL-10 DNA, resulted in a significant change in Th subset balance following HSV infection. Our results indicate that the modulating effect of IL-4 or IL-10 DNA may proceed by different mechanisms. Furthermore, our results suggest that surface administration of cytokine DNA is a convenient means of modulating immunoinflammatory lesions.

Citing Articles

Gene Therapy in the Anterior Eye Segment.

Amador C, Shah R, Ghiam S, Kramerov A, Ljubimov A Curr Gene Ther. 2021; 22(2):104-131.

PMID: 33902406 PMC: 8531184. DOI: 10.2174/1566523221666210423084233.

Targeting herpetic keratitis by gene therapy.

Elbadawy H, Gailledrat M, Desseaux C, Ponzin D, Ferrari S J Ophthalmol. 2013; 2012:594869.

PMID: 23326647 PMC: 3541562. DOI: 10.1155/2012/594869.

Immunomodulation by topical particle-mediated administration of cytokine plasmid DNA suppresses herpetic stromal keratitis without impairment of antiviral defense.

Bauer D, Lu M, Wasmuth S, Li H, Yang Y, Roggendorf M Graefes Arch Clin Exp Ophthalmol. 2005; 244(2):216-25.

PMID: 16047184 DOI: 10.1007/s00417-005-0070-z.

The dominant-negative herpes simplex virus type 1 (HSV-1) recombinant CJ83193 can serve as an effective vaccine against wild-type HSV-1 infection in mice.

Augustinova H, Hoeller D, Yao F J Virol. 2004; 78(11):5756-65.

PMID: 15140973 PMC: 415800. DOI: 10.1128/JVI.78.11.5756-5765.2004.

Protection against recurrent ocular herpes simplex virus type 1 disease after therapeutic vaccination of latently infected mice.

Richards C, Case R, Hirst T, Hill T, Williams N J Virol. 2003; 77(12):6692-9.

PMID: 12767989 PMC: 156198. DOI: 10.1128/jvi.77.12.6692-6699.2003.

References

Spear P, Roizman B . Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion. J Virol. 1972; 9(1):143-59. PMC: 356272. DOI: 10.1128/JVI.9.1.143-159.1972. View

Daheshia M, Kuklin N, Manickan E, Chun S, Rouse B . Immune induction and modulation by topical ocular administration of plasmid DNA encoding antigens and cytokines. Vaccine. 1998; 16(11-12):1103-10. DOI: 10.1016/s0264-410x(98)80105-9. View

Hendricks R, Tao M, Glorioso J . Alterations in the antigenic structure of two major HSV-1 glycoproteins, gC and gB, influence immune regulation and susceptibility to murine herpes keratitis. J Immunol. 1989; 142(1):263-9. View

Hendricks R, Tumpey T, Finnegan A . IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice. J Immunol. 1992; 149(9):3023-8. View

Niemialtowski M, Rouse B . Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. J Immunol. 1992; 149(9):3035-9. View

Jayaraman S, Heiligenhaus A, Rodriguez A, Soukiasian S, Dorf M, Foster C . Exacerbation of murine herpes simplex virus-mediated stromal keratitis by Th2 type T cells. J Immunol. 1993; 151(10):5777-89. View

Rogy M, Auffenberg T, Espat N, Philip R, Remick D, Wollenberg G . Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses. J Exp Med. 1995; 181(6):2289-93. PMC: 2192075. DOI: 10.1084/jem.181.6.2289. View

Manickan E, Rouse R, Yu Z, Wire W, Rouse B . Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes. J Immunol. 1995; 155(1):259-65. View

Manickan E, Francotte M, Kuklin N, Dewerchin M, Molitor C, Gheysen D . Vaccination with recombinant vaccinia viruses expressing ICP27 induces protective immunity against herpes simplex virus through CD4+ Th1+ T cells. J Virol. 1995; 69(8):4711-6. PMC: 189277. DOI: 10.1128/JVI.69.8.4711-4716.1995. View

10.

Nair S, Buiting A, Rouse R, van Rooijen N, Huang L, Rouse B . Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. Int Immunol. 1995; 7(4):679-88. DOI: 10.1093/intimm/7.4.679. View

11.

Ertl H, Xiang Z . Novel vaccine approaches. J Immunol. 1996; 156(10):3579-82. View

12.

Kumar V, Sercarz E . Genetic vaccination: the advantages of going naked. Nat Med. 1996; 2(8):857-9. DOI: 10.1038/nm0896-857. View

13.

Ulmer J, Sadoff J, Liu M . DNA vaccines. Curr Opin Immunol. 1996; 8(4):531-6. DOI: 10.1016/s0952-7915(96)80042-2. View

14.

Li X, Chopra R, Chou T, Schofield B, Wills-Karp M, Huang S . Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice. J Immunol. 1996; 157(8):3216-9. View

15.

Kuklin N, Daheshia M, Karem K, Manickan E, Rouse B . Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization. J Virol. 1997; 71(4):3138-45. PMC: 191446. DOI: 10.1128/JVI.71.4.3138-3145.1997. View

16.

Manickan E, Karem K, Rouse B . DNA vaccines -- a modern gimmick or a boon to vaccinology?. Crit Rev Immunol. 1997; 17(2):139-54. DOI: 10.1615/critrevimmunol.v17.i2.20. View

17.

Daheshia M, Kuklin N, Kanangat S, Manickan E, Rouse B . Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10. J Immunol. 1997; 159(4):1945-52. View

18.

Groux H, OGarra A, Bigler M, Rouleau M, Antonenko S, De Vries J . A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997; 389(6652):737-42. DOI: 10.1038/39614. View

19.

Manickan E, Yu Z, Rouse B . DNA immunization of neonates induces immunity despite the presence of maternal antibody. J Clin Invest. 1997; 100(9):2371-5. PMC: 508435. DOI: 10.1172/JCI119777. View

20.

Chow Y, Chiang B, Lee Y, Chi W, Lin W, Chen Y . Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes. J Immunol. 1998; 160(3):1320-9. View