Duration of Protective Immunity Conferred by Maternal Tetanus Toxoid Immunization: Further Evidence from Matlab, Bangladesh

Overview

Journal Am J Public Health

Specialty Public Health

Date 1998 Jun 10

PMID 9618617

Citations 17

Authors

M A Koenig

N C Roy

T McElrath

M Shahidullah

B Wojtyniak

Affiliations

Soon will be listed here.

Abstract

Objectives: Although maternal tetanus immunization has been shown to be highly effective in the prevention of neonatal tetanus, unresolved questions remain concerning the required minimum number of doses and the resulting duration of effective immunity. This study examined the duration of effective immunity against neonatal tetanus provided by maternal tetanus immunization.

Methods: A randomized, double-blind cholera vaccine trial of 41,571 children and nonpregnant adult women carried out in 1974 in the Matlab comparison area of rural Bangladesh provided a unique opportunity to address dose and immunity issues.

Results: Children of women who received either 1 or 2 injections of tetanus toxoid experienced 4- to 14-day mortality levels consistently lower than those of children of unimmunized mothers. Analysis of neonatal-tetanus-related mortality showed that 2 injections of tetanus toxoid provided significant protection for subsequent durations of up to 12 or 13 years.

Conclusions: The data demonstrate that a limited-dose regimen of maternal tetanus toxoid provides significant and extended protection against the risk of neonatal tetanus death.

Citing Articles

Trends and determinants of taking tetanus toxoid vaccine among women during last pregnancy in Bangladesh: Country representative survey from 2006 to 2019.

Amin M, Roy N, Meem A, Hossain E, Aktarujjaman M PLoS One. 2022; 17(10):e0276417.

PMID: 36264922 PMC: 9584373. DOI: 10.1371/journal.pone.0276417.

Do inequalities exist in the disadvantaged populations? Levels and trends of full and on-time vaccination coverage in two Nairobi urban informal settlements.

Mutua M, Mohamed S, Iddi S, Muyingo S, Mwangi B, Kadengye D Glob Epidemiol. 2020; 2:100044.

PMID: 33363280 PMC: 7756173. DOI: 10.1016/j.gloepi.2020.100044.

Preference in the use of full childhood immunizations in Ethiopia: the role of maternal health services.

Regassa N, Bird Y, Moraros J Patient Prefer Adherence. 2019; 13:91-99.

PMID: 30662259 PMC: 6329350. DOI: 10.2147/PPA.S189844.

A New Look at Care in Pregnancy: Simple, Effective Interventions for Neglected Populations.

Hodgins S, Tielsch J, Rankin K, Robinson A, Kearns A, Caglia J PLoS One. 2016; 11(8):e0160562.

PMID: 27537281 PMC: 4990268. DOI: 10.1371/journal.pone.0160562.

Vaccination and all-cause child mortality from 1985 to 2011: global evidence from the Demographic and Health Surveys.

McGovern M, Canning D Am J Epidemiol. 2015; 182(9):791-8.

PMID: 26453618 PMC: 4757942. DOI: 10.1093/aje/kwv125.

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