Helicobacter Pylori Generates Superoxide Radicals and Modulates Nitric Oxide Metabolism

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1998 Jun 11

PMID 9603902

Citations 30

Authors

K Nagata

H Yu

M Nishikawa

M KASHIBA

A Nakamura

E F Sato

T Tamura

M Inoue

Affiliations

Soon will be listed here.

Abstract

During studies of the bactericidal action of nitric oxide (NO), we found that it reversibly inhibited the respiration of Escherichia coli and irreversibly inhibited the respiration of Helicobacter pylori. Peroxynitrite, a reaction product of NO and superoxide, irreversibly inhibited the respiration of both H. pylori and E. coli. H. pylori, but not E. coli, generated substantial amounts of superoxide radicals. These results suggest that NO directly inhibits the respiration of E. coli whereas it rapidly reacts with endogenously generated superoxide radicals in H. pylori. The resulting peroxynitrite inactivates the respiration of H. pylori.

Citing Articles

infection-A risk factor for lipid peroxidation and superoxide dismutase over-activity: A cross-sectional study among patients with dyspepsia in Cameroon.

Faujo Nintewoue G, Tali Nguefak L, Ngatcha G, Tagni S, Talla P, Menzy Moungo-Ndjole C JGH Open. 2023; 7(9):618-628.

PMID: 37744703 PMC: 10517442. DOI: 10.1002/jgh3.12958.

Everolimus ameliorates Helicobacter pylori infection-induced inflammation in gastric epithelial cells.

Liu J, Zhang F, Zhang Z, Zheng C Bioengineered. 2022; 13(5):11361-11372.

PMID: 35506423 PMC: 9276037. DOI: 10.1080/21655979.2021.2018533.

Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis.

Zhou J, Zhang L, Zeng L, Yu L, Duan Y, Shen S Nat Commun. 2021; 12(1):6932.

PMID: 34836944 PMC: 8626469. DOI: 10.1038/s41467-021-27148-0.

Gastric Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model.

Berlamont H, Bruggeman A, Bauwens E, Vandendriessche C, Clarebout E, Xie J Int J Mol Sci. 2021; 22(21).

PMID: 34768765 PMC: 8582972. DOI: 10.3390/ijms222111328.

DNA Hypermethylation Downregulates Telomerase Reverse Transcriptase (TERT) during -Induced Chronic Inflammation.

Bussiere F, Michel V, Fernandes J, Costa L, Camilo V, Nigro G J Oncol. 2020; 2019:5415761.

PMID: 32082377 PMC: 7012206. DOI: 10.1155/2019/5415761.