In Vitro Activities of Clinafloxacin Against Contemporary Clinical Bacterial Isolates from 10 North American Centers
Overview
Affiliations
Clinafloxacin was more active than ciprofloxacin against 4,213 aerobic and facultative anaerobic bacterial isolates from 10 medical centers, as tested by broth microdilution and disk diffusion methods. The percentage of 201 anaerobes susceptible to clinafloxacin by broth microdilution was comparable to cefoxitin. Our data support the proposed disk diffusion interpretive criteria for aerobic bacteria with 5-microg clinafloxacin disks.
A critical review of the fluoroquinolones: focus on respiratory infections.
Zhanel G, Ennis K, Vercaigne L, Walkty A, Gin A, Embil J Drugs. 2002; 62(1):13-59.
PMID: 11790155 DOI: 10.2165/00003495-200262010-00002.
Drug interactions with clinafloxacin.
Randinitis E, Alvey C, Koup J, Rausch G, Abel R, Bron N Antimicrob Agents Chemother. 2001; 45(9):2543-52.
PMID: 11502527 PMC: 90690. DOI: 10.1128/AAC.45.9.2543-2552.2001.
Clinafloxacin pharmacokinetics in subjects with various degrees of renal function.
Randinitis E, Koup J, Rausch G, Abel R, Bron N, Hounslow N Antimicrob Agents Chemother. 2001; 45(9):2536-42.
PMID: 11502526 PMC: 90689. DOI: 10.1128/AAC.45.9.2536-2542.2001.
Pharmacokinetics of clinafloxacin after single and multiple doses.
Randinitis E, Brodfuehrer J, Eiseman I, Vassos A Antimicrob Agents Chemother. 2001; 45(9):2529-35.
PMID: 11502525 PMC: 90688. DOI: 10.1128/AAC.45.9.2529-2535.2001.
Linde H, Schmidt M, Fuchs E, Reischl U, Niller H, Lehn N Antimicrob Agents Chemother. 2001; 45(5):1553-7.
PMID: 11302827 PMC: 90505. DOI: 10.1128/AAC.45.5.1553-1557.2001.