CD28-B7 Costimulatory Blockade by CTLA4Ig Delays the Development of Retrovirus-induced Murine AIDS

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1998 May 30

PMID 9573306

Citations 6

Authors

L de Leval

S Colombi

S Debrus

M A Demoitie

R Greimers

P Linsley

M Moutschen

J Boniver

Affiliations

Soon will be listed here.

Abstract

Mouse AIDS (MAIDS) induced in C57BL/6 mice by infection with a replication-defective retrovirus (Du5H) combines extensive lymphoproliferation and profound immunodeficiency. Although B cells are the main target of viral infection, recent research has focused on CD4(+) T cells, the activation of which is a key event in MAIDS induction and progression. A preliminary observation of increased expression of B7 molecules on B cells in MAIDS prompted us to address the possible involvement of the CD28/B7 costimulatory pathway in MAIDS. Mice infected with the MAIDS-inducing viral preparation were treated with murine fusion protein CTLA4Ig (3 x 50 microg/week given intraperitoneally), a competitive inhibitor of physiological CD28-B7 interactions. In CTLA4Ig-treated animals, the onset of the disease was delayed, lymphoproliferation progressed at a much slower rate than in untreated mice, and the loss of in vitro responsiveness to mitogens was reduced. Relative expression of Du5H did not differ between treated and untreated animals. These results suggest that the CD28/B7 costimulatory pathway contributes to MAIDS development.

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References

Bretscher P . The two-signal model of lymphocyte activation twenty-one years later. Immunol Today. 1992; 13(2):74-6. DOI: 10.1016/0167-5699(92)90138-W. View

Morse 3rd H, Chattopadhyay S, Makino M, Fredrickson T, Hugin A, Hartley J . Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS. 1992; 6(7):607-21. DOI: 10.1097/00002030-199207000-00001. View

Liu Y, Linsley P . Costimulation of T-cell growth. Curr Opin Immunol. 1992; 4(3):265-70. DOI: 10.1016/0952-7915(92)90075-p. View

Galvin F, Freeman G, Hall Jr W, Benacerraf B, NADLER L, Reiser H . Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation. J Immunol. 1992; 149(12):3802-8. View

Linsley P, Ledbetter J . The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol. 1993; 11:191-212. DOI: 10.1146/annurev.iy.11.040193.001203. View

Suzuki K, Makino M, Okada Y, Kinoshita J, Yui R, Kanazawa H . Exocrinopathy resembling Sjögren's syndrome induced by a murine retrovirus. Lab Invest. 1993; 69(4):430-5. View

Freeman G, Borriello F, Hodes R, Reiser H, Gribben J, Ng J . Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. J Exp Med. 1993; 178(6):2185-92. PMC: 2191273. DOI: 10.1084/jem.178.6.2185. View

Moutschen M, Colombi S, Deprez M, van Wijk F, Hotermans C, Martin M . Population dynamics of CD4+ T cells lacking Thy-1 in murine retrovirus-induced immunodeficiency syndrome (MAIDS). Scand J Immunol. 1994; 39(2):216-24. DOI: 10.1111/j.1365-3083.1994.tb03363.x. View

Simard C, Huang M, Jolicoeur P . Murine AIDS is initiated in the lymph nodes draining the site of inoculation, and the infected B cells influence T cells located at distance, in noninfected organs. J Virol. 1994; 68(3):1903-12. PMC: 236652. DOI: 10.1128/JVI.68.3.1903-1912.1994. View

10.

Klaus S, Pinchuk L, Ochs H, LAW C, Fanslow W, Armitage R . Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. J Immunol. 1994; 152(12):5643-52. View

11.

Hathcock K, Laszlo G, Pucillo C, Linsley P, Hodes R . Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med. 1994; 180(2):631-40. PMC: 2191623. DOI: 10.1084/jem.180.2.631. View

12.

Giese N, Giese T, Morse 3rd H . Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells. J Virol. 1994; 68(9):5819-24. PMC: 236986. DOI: 10.1128/JVI.68.9.5819-5824.1994. View

13.

June C, Bluestone J, Nadler L, Thompson C . The B7 and CD28 receptor families. Immunol Today. 1994; 15(7):321-31. DOI: 10.1016/0167-5699(94)90080-9. View

14.

Uehara S, Hitoshi Y, Numata F, Makino M, Howard M, Mizuochi T . An IFN-gamma-dependent pathway plays a critical role in the pathogenesis of murine immunodeficiency syndrome induced by LP-BM5 murine leukemia virus. Int Immunol. 1994; 6(12):1937-47. DOI: 10.1093/intimm/6.12.1937. View

15.

Muraille E, De Smedt T, Thielemans K, Urbain J, Moser M, Leo O . Activation of murine T cells by bacterial superantigens requires B7-mediated costimulation. Cell Immunol. 1995; 162(2):315-20. DOI: 10.1006/cimm.1995.1084. View

16.

Linsley P . Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?. J Exp Med. 1995; 182(2):289-92. PMC: 2192144. DOI: 10.1084/jem.182.2.289. View

17.

Morse 3rd H, Giese N, Morawetz R, Tang Y, Gazzinelli R, Kim W . Cells and cytokines in the pathogenesis of MAIDS, a retrovirus-induced immunodeficiency syndrome of mice. Springer Semin Immunopathol. 1995; 17(2-3):231-45. DOI: 10.1007/BF00196167. View

18.

Green K, Crassi K, Laman J, Schoneveld A, Strawbridge R, Foy T . Antibody to the ligand for CD40 (gp39) inhibits murine AIDS-associated splenomegaly, hypergammaglobulinemia, and immunodeficiency in disease-susceptible C57BL/6 mice. J Virol. 1996; 70(4):2569-75. PMC: 190103. DOI: 10.1128/JVI.70.4.2569-2575.1996. View

19.

Lane P, Haller C, McConnell F . Evidence that induction of tolerance in vivo involves active signaling via a B7 ligand-dependent mechanism: CTLA4-Ig protects V beta 8+ T cells from tolerance induction by the superantigen staphylococcal enterotoxin B. Eur J Immunol. 1996; 26(4):858-62. DOI: 10.1002/eji.1830260420. View

20.

Giese N, Gazzinelli R, Actor J, Morawetz R, Sarzotti M, Morse 3rd H . Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS. Immunology. 1996; 87(3):467-74. PMC: 1384118. DOI: 10.1046/j.1365-2567.1996.492569.x. View