Enkephalin: a Potential Modulator of Noradrenaline Release in Rat Brain

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1976 Aug 1

PMID 954850

Citations 16

Authors

H D Taube

E Borowski

T Endo

K Starke

Affiliations

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Abstract

In slices of rat occipital cortex preincubated with 3H-noradrenaline, methioine-enkephalin diminished the overflow of tritium evoked by electrical field stimulation or by 20 mM potassium. The effect was not modified by phentolamine, but was antagonized by naloxone. Giver alone, naloxone slightly increased the potassium-evoked overflow. It is concluded that enkephalin reduces transmitter release from cerebrocortical noradrenergic nerve endings. One-function of endogenous opiate receptor ligands may be presynaptic inhibition of central noradrenergic transmission.

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Action of enkephalin analogues and morphine on brain acetylcholine release: differential reversal by naloxone and an opiate pentapeptide.

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