Capture of an Early Fusion-active Conformation of HIV-1 Gp41

Overview

Journal Nat Struct Biol

Specialty Cell Biology

Date 1998 Apr 18

PMID 9546217

Citations 258

Authors

R A Furuta

C T Wild

Y Weng

C D Weiss

Affiliations

Soon will be listed here.

Abstract

Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformational changes involving the coiled coil domain of gp41 are required for entry. Capture of this fusion-active conformation of Env provides insights into the early events leading to Env-mediated membrane fusion.

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