Modes of Seoul Virus Infections: Persistency in Newborn Rats and Transiency in Adult Rats

Overview

Journal Arch Virol

Specialty Microbiology

Date 1996 Jan 1

PMID 9526540

Citations 16

Authors

H Kariwa

M Kimura

S Yoshizumi

J Arikawa

K Yoshimatsu

I Takashima

N Hashimoto

Affiliations

Soon will be listed here.

Abstract

To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 days post inoculation (d.p.i.) by nested reverse transcriptase PCR. On the other hand, when 7-week-old rats were infected with this virus, viral genome was detected only in the lungs from 3 to 50 d.p.i. The neutralizing antibody titers of rats inoculated at 1-day of age were higher than those of rats inoculated at 7 weeks of age. In both age groups, however, the IgG avidity of antibody increased along with the course of infection. We found that urban rats (Rattus norvegicus) infected early in life harbored the virus for more than 6 months.

Citing Articles

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Innate Immunity to Orthohantaviruses: Could Divergent Immune Interactions Explain Host-specific Disease Outcomes?.

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Seoul Virus in Pet and Feeder Rats in The Netherlands.

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Orthohantavirus Isolated in Reservoir Host Cells Displays Minimal Genetic Changes and Retains Wild-Type Infection Properties.

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