Epidemiological Studies of Hemorrhagic Fever with Renal Syndrome (HFRS) Related Virus Infection Among Urban Rats in Hokkaido, Japan

Overview

Journal Arch Virol

Specialty Microbiology

Date 1986 Jan 1

PMID 2871823

Citations 10

Authors

J Arikawa

I Takashima

N Hashimoto

K Takahashi

K Yagi

K Hattori

Affiliations

Soon will be listed here.

Abstract

Seroepidemiological studies of hemorrhagic fever with renal syndrome (HFRS) virus infection were carried out among urban rats (Rattus norvegicus and Rattus rattus) and small field rodents in Hokkaido, Japan. An urban rat colony that was seropositive to SR-11 strain of HFRS virus (laboratory rat origin) was demonstrated in February 1983 at a dumping ground area of Kami-iso Town near Hakodate port. An HFRS-related virus, named KI-262 strain, was isolated from the lung tissue of a seropositive rat using Vero-E6 cell culture. Antigenicity of the isolate was closely related to Hantaan 76-118 and SR-11 strains by the indirect immunofluorescent antibody (IFA) test. No seropositive rat was found among the 861 rats captured in 38 other regions. It is unclear whether or not the infected rats in the positive area were introduced from abroad, though the area is located near Hakodate International Port. Furthermore, higher positive rates of urban rats in the Kami-iso area were observed in the spring and winter than in the summer and fall. Significantly high proportion of positive cases was observed among adult rats (six months or older) than among younger animals. The seasonal and age distribution of positive cases suggested that the virus was not readily transmitted from one infected rat to another. One seropositive case of a small field mouse (Clethrionomys rufocanus bedfordiae) was detected around the Kami-iso area.

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References

Song G, Hang C, Qui X, Ni D, Liao H, Gao G . Etiologic studies of epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome). J Infect Dis. 1983; 147(4):654-9. DOI: 10.1093/infdis/147.4.654. View

BRUMMER-KORVENKONTIO M, Vaheri A, Hovi T, von Bonsdorff C, Vuorimies J, Manni T . Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis. 1980; 141(2):131-4. DOI: 10.1093/infdis/141.2.131. View

Sugiyama K, Morita C, Matsuura Y, Shiga S, Komatsu T, Morikawa S . Isolation of a virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area. J Infect Dis. 1984; 149(3):473. DOI: 10.1093/infdis/149.3.473. View

LoGRIPPO G, Hartman F . Antigenicity of beta-propiolactone-inactivated virus vaccines. J Immunol. 1955; 75(2):123-8. View

Morita C, Sugiyama K, Matsuura Y, Kitamura T, Komatsu T, Akao Y . Detection of antibody against hemorrhagic fever with renal syndrome (HFRS) virus in sera of house rats captured in port areas of Japan. Jpn J Med Sci Biol. 1983; 36(1):55-7. DOI: 10.7883/yoken1952.36.55. View

Kitamura T, Morita C, Komatsu T, Sugiyama K, Arikawa J, Shiga S . Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Jpn J Med Sci Biol. 1983; 36(1):17-25. DOI: 10.7883/yoken1952.36.17. View

Lee H, Lee P, Baek L, Song C, Seong I . Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg. 1981; 30(5):1106-12. DOI: 10.4269/ajtmh.1981.30.1106. View

Yamanishi K, Dantas J, Takahashi M, Yamanouchi T, Domae K, Kawamata J . Isolation of hemorrhagic fever with renal syndrome (HFRS) virus from a tumor specimen in a rat. Biken J. 1983; 26(4):155-60. View

Gavrilovskaya I, Apekina N, Myasnikov YuA , Bernshtein A, Ryltseva E, Gorbachkova E . Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European U.S.S.R. Arch Virol. 1983; 75(4):313-6. DOI: 10.1007/BF01314898. View

10.

. Preliminary evidence that Hantaan or a closely related virus is enzootic in domestic rodents. N Engl J Med. 1982; 307(10):623-5. DOI: 10.1056/NEJM198209023071013. View

11.

Dai Z, Wang J, Yang P, Xu Z . Epidemiologic and clinical studies of epidemic hemorrhagic fever. Chin Med J (Engl). 1981; 94(3):143-8. View

12.

. Haemorrhagic fever with renal syndrome: memorandum from a WHO meeting. Bull World Health Organ. 1983; 61(2):269-75. PMC: 2536130. View

13.

Butkus D . Epidemic hemorrhagic fever with renal syndrome. A broadening horizon. Arch Intern Med. 1983; 143(12):2299-300. View

14.

Arikawa J, Takashima I, Hashimoto N . Cell fusion by haemorrhagic fever with renal syndrome (HFRS) viruses and its application for titration of virus infectivity and neutralizing antibody. Arch Virol. 1985; 86(3-4):303-13. DOI: 10.1007/BF01309834. View

15.

McCormick J, Sasso D, Palmer E, Kiley M . Morphological identification of the agent of Korean haemorrhagic fever (Hantaan virus)as a member of the Bunyaviridae. Lancet. 1982; 1(8275):765-8. DOI: 10.1016/s0140-6736(82)91812-8. View

16.

Lee H, Baek L, Johnson K . Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J Infect Dis. 1982; 146(5):638-44. DOI: 10.1093/infdis/146.5.638. View

17.

Lee P, Amyx H, Gajdusek D, Yanagihara R, Goldgaber D, Gibbs Jr C . New hemorrhagic fever with renal syndrome-related virus in rodents in the United States. Lancet. 1982; 2(8312):1405. View

18.

FRENCH G, Foulke R, BRAND O, Eddy G, Lee H, Lee P . Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin. Science. 1981; 211(4486):1046-8. DOI: 10.1126/science.6110243. View

19.

Umenai T, Lee H, Lee P, Saito T, Toyoda T, Hongo M . Korean haemorrhagic fever in staff in an animal laboratory. Lancet. 1979; 1(8130):1314-6. DOI: 10.1016/s0140-6736(79)91948-2. View

20.

LeDuc J, Smith G, Johnson K . Hantaan-like viruses from domestic rats captured in the United States. Am J Trop Med Hyg. 1984; 33(5):992-8. DOI: 10.4269/ajtmh.1984.33.992. View