Protein Aggregation: Folding Aggregates, Inclusion Bodies and Amyloid

Overview

Journal Fold Des

Specialties Biochemistry
Biotechnology

Date 1998 Mar 21

PMID 9502314

Citations 294

Authors

A L Fink

Affiliations

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Abstract

Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding aggregates. Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.

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