» Articles » PMID: 9493744

Heritability of Poor Language Achievement Among Twins

Overview
Date 1998 Mar 11
PMID 9493744
Citations 42
Authors
Affiliations
Soon will be listed here.
Abstract

In order to examine the basis of familial associations with poor language achievement, 62 twinship pairs and 3 sets of triplets were studied in which at least one member presented poor oral language status in the absence of other developmental or sensory impairments. Rates of concordance for poor language were compared between the monozygotic (MZ) and dizygotic (DZ) pairs. Concordance for the MZ pairs was .96, whereas it was .69 for the DZ pairs. The DeFries-Fulker method for computing heritability of extreme scores was employed yielding a h2g of .45. Similar results were obtained for those pairs containing only children with performance IQs above 85, but with at least one member having language below -1 SD. A comparison of DZ twins with singleton sibling pairs with at least one affected member and of similar age showed that DZ twins were more similar with respect to language achievement than singleton pairs. Thus, twinning appeared to have influenced twin resemblance among those where at least one member presented poor language achievement. These results support the hypothesis that genetic factors contribute to the liability of poor language achievement in children who do not present other developmental or sensory disorders.

Citing Articles

Lingo: an automated, web-based deep phenotyping platform for language ability.

Casten L, Koomar T, Elsadany M, McKone C, Tysseling B, Sasidharan M medRxiv. 2024; .

PMID: 38585791 PMC: 10996758. DOI: 10.1101/2024.03.29.24305034.


The Musical Abilities, Pleiotropy, Language, and Environment (MAPLE) Framework for Understanding Musicality-Language Links Across the Lifespan.

Nayak S, Coleman P, Ladanyi E, Nitin R, Gustavson D, Fisher S Neurobiol Lang (Camb). 2023; 3(4):615-664.

PMID: 36742012 PMC: 9893227. DOI: 10.1162/nol_a_00079.


Executive Function, Working Memory, and Verbal Fluency in Relation to Non-Verbal Intelligence in Greek-Speaking School-Age Children with Developmental Language Disorder.

Ralli A, Chrysochoou E, Roussos P, Diakogiorgi K, Dimitropoulou P, Filippatou D Brain Sci. 2021; 11(5).

PMID: 34066872 PMC: 8151609. DOI: 10.3390/brainsci11050604.


A rare missense variant in the ATP2C2 gene is associated with language impairment and related measures.

Martinelli A, Rice M, Talcott J, Diaz R, Smith S, Raza M Hum Mol Genet. 2021; 30(12):1160-1171.

PMID: 33864365 PMC: 8188402. DOI: 10.1093/hmg/ddab111.


Reduced left-lateralized pattern of event-related EEG oscillations in infants at familial risk for language and learning impairment.

Cantiani C, Ortiz-Mantilla S, Riva V, Piazza C, Bettoni R, Musacchia G Neuroimage Clin. 2019; 22:101778.

PMID: 30901712 PMC: 6428938. DOI: 10.1016/j.nicl.2019.101778.