Fibroblast Growth Factor 2 Control of Vascular Tone

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 1998 Feb 14

PMID 9461194

Citations 127

Authors

M Zhou

R L Sutliff

R J Paul

J N Lorenz

J B Hoying

C C Haudenschild

M Yin

J D Coffin

L Kong

E G Kranias

W Luo

G P Boivin

J J Duffy

S A Pawlowski

T Doetschman

Affiliations

Soon will be listed here.

Abstract

Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion, inflammation, vessel injury/repair, wound healing, temperature regulation, digestion, exercise physiology, and metabolism. Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers of vessel walls, functions in vascular tone control. Fgf2 knockout mice are morphologically normal and display decreased vascular smooth muscle contractility, low blood pressure and thrombocytosis. Following intra-arterial mechanical injury, FGF2-deficient vessels undergo a normal hyperplastic response. These results force us to reconsider the function of FGF2 in vascular development and homeostasis in terms of vascular tone control.

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