Alpha 2.0

» Articles » PMID: 9435307

A Leukocyte Homologue of the IL-8 Receptor CXCR-2 Mediates the Accumulation of Macrophages in Atherosclerotic Lesions of LDL Receptor-deficient Mice

Overview

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1998 Feb 7

PMID 9435307

Citations 111

Authors

Authors

W A Boisvert

R Santiago

L K Curtiss

R A Terkeltaub

Affiliations

Affiliations

Soon will be listed here.

Abstract

Chronic macrophage-mediated inflammation is central to atherosclerosis. A role of the monocyte chemotactic and activating C-C chemokine JE/monocyte chemotactic protein-1 has been proposed. However, the human C-X-C chemokines growth-regulated oncogene (GROalpha) and IL-8, and their shared receptor, CXCR-2, also can be expressed at sites of chronic inflammation. Because we detected CXCR-2 in the intima of human atherosclerotic lesions, we examined the role of leukocyte CXCR-2 expression in affecting lesion cellularity. Atherosclerosis-susceptible LDL receptor-deficient mice were irradiated, successfully repopulated with bone marrow cells that either lacked or expressed mIL-8RH (the homologue of CXCR-2), and fed an atherogenic diet for 16 wk. In recipients of mIL-8RH+/+ marrow, mIL-8RH colocalized with densely accumulated intimal MOMA-2 positive macrophages. In contrast, lesions in recipients of mIL-8RH-/- marrow lacked mIL-8RH, had little intimal MOMA-2 staining, and were less extensive. The mIL-8RH ligand KC/GROalpha was detected in the intima of all aortic atherosclerotic lesions. Thus, the capacity of leukocytes to express mIL-8RH, and associated intralesional expression of its ligands such as KC/GROalpha, mediated the intimal accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.

Citing Articles

Resident memory CD8(+) T cells dominate lymphoid immune cell population in human pancreatic islets in health and type 2 diabetes.

Radenkovic M, Arvastsson J, Sarmiento L, Cilio C BMJ Open Diabetes Res Care. 2025; 13(2).

PMID: 40068923 PMC: 11904352. DOI: 10.1136/bmjdrc-2024-004559.

Cytokine Levels in Experimental Branch Retinal Vein Occlusion Treated With Either Bevacizumab or Triamcinolone Acetonide.

McAllister I, Vijayasekaran S, McLenachan S, Bhikoo R, Chen F, Zhang D Transl Vis Sci Technol. 2024; 13(6):13.

PMID: 38899953 PMC: 11193067. DOI: 10.1167/tvst.13.6.13.

Identification of a functional missense variant in the matrix metallopeptidase 10 (MMP10) gene in two families with premature myocardial infarction.

Verovenko V, Tennstedt S, Kleinecke M, Kessler T, Schunkert H, Erdmann J Sci Rep. 2024; 14(1):12212.

PMID: 38806571 PMC: 11133425. DOI: 10.1038/s41598-024-62878-3.

Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation.

Mulholland M, Depuydt M, Jakobsson G, Ljungcrantz I, Grentzmann A, To F Cardiovasc Res. 2024; 120(6):581-595.

PMID: 38563353 PMC: 11074796. DOI: 10.1093/cvr/cvae046.

Chemokine Binding to Tenascin-C Influences Chemokine-Induced Immune Cell Migration.

Domaingo A, Jokesch P, Schweiger A, Gschwandtner M, Gerlza T, Koch M Int J Mol Sci. 2023; 24(19).

PMID: 37834140 PMC: 10572825. DOI: 10.3390/ijms241914694.

References

1.

Hamilton T, Major J . Oxidized LDL potentiates LPS-induced transcription of the chemokine KC gene. J Leukoc Biol. 1996; 59(6):940-7. DOI: 10.1002/jlb.59.6.940. View

2.

Prescott S, McIntyre T, Zimmerman G, Stafforini D . Inflammation as an early component of atherosclerosis and vascular damage--a role for P-selectin and platelet-activating factor. Jpn Circ J. 1996; 60(3):137-41. DOI: 10.1253/jcj.60.137. View

3.

Murphy W, Tian Z, Asai O, Funakoshi S, Rotter P, Henry M . Chemokines and T lymphocyte activation: II. Facilitation of human T cell trafficking in severe combined immunodeficiency mice. J Immunol. 1996; 156(6):2104-11. View

4.

Apostolopoulos J, Davenport P, Tipping P . Interleukin-8 production by macrophages from atheromatous plaques. Arterioscler Thromb Vasc Biol. 1996; 16(8):1007-12. DOI: 10.1161/01.atv.16.8.1007. View

5.

Roselaar S, Kakkanathu P, Daugherty A . Lymphocyte populations in atherosclerotic lesions of apoE -/- and LDL receptor -/- mice. Decreasing density with disease progression. Arterioscler Thromb Vasc Biol. 1996; 16(8):1013-8. DOI: 10.1161/01.atv.16.8.1013. View

6.

Lundahl J, Skold C, Hallden G, Hallgren M, Eklund A . Monocyte and neutrophil adhesion to matrix proteins is selectively enhanced in the presence of inflammatory mediators. Scand J Immunol. 1996; 44(2):143-9. DOI: 10.1046/j.1365-3083.1996.d01-296.x. View

7.

Howard O, Ben-Baruch A, Oppenheim J . Chemokines: progress toward identifying molecular targets for therapeutic agents. Trends Biotechnol. 1996; 14(2):46-51. DOI: 10.1016/0167-7799(96)80920-6. View

8.

Hoch R, Schraufstatter I, Cochrane C . In vivo, in vitro, and molecular aspects of interleukin-8 and the interleukin-8 receptors. J Lab Clin Med. 1996; 128(2):134-45. DOI: 10.1016/s0022-2143(96)90005-0. View

9.

Ahuja S, Murphy P . The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8.... J Biol Chem. 1996; 271(34):20545-50. DOI: 10.1074/jbc.271.34.20545. View

10.

Santamaria Babi L, Moser B, Perez Soler M, Moser R, Loetscher P, Villiger B . The interleukin-8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells. Eur J Immunol. 1996; 26(9):2056-61. DOI: 10.1002/eji.1830260914. View

11.

Wang J, Zhang Y, Kasahara T, Harada A, Matsushima K, Mukaida N . Detection of mouse IL-8 receptor homologue expression on peripheral blood leukocytes and mature myeloid lineage cells in bone marrow. J Leukoc Biol. 1996; 60(3):372-81. DOI: 10.1002/jlb.60.3.372. View

12.

Kunkel S . Th1- and Th2-type cytokines regulate chemokine expression. Biol Signals. 1996; 5(4):197-202. DOI: 10.1159/000109190. View

13.

Broxmeyer H, Cooper S, Cacalano G, Hague N, Bailish E, Moore M . Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue. J Exp Med. 1996; 184(5):1825-32. PMC: 2192871. DOI: 10.1084/jem.184.5.1825. View

14.

Dunstan C, Salafranca M, Adhikari S, Xia Y, Feng L, Harrison J . Identification of two rat genes orthologous to the human interleukin-8 receptors. J Biol Chem. 1996; 271(51):32770-6. DOI: 10.1074/jbc.271.51.32770. View

15.

Watanabe T, Haraoka S, Shimokama T . Inflammatory and immunological nature of atherosclerosis. Int J Cardiol. 1997; 54 Suppl:S51-60. DOI: 10.1016/s0167-5273(96)88773-0. View

16.

Boisvert W, Spangenberg J, Curtiss L . Role of leukocyte-specific LDL receptors on plasma lipoprotein cholesterol and atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 1997; 17(2):340-7. DOI: 10.1161/01.atv.17.2.340. View

17.

Ridker P, Cushman M, Stampfer M, Tracy R, Hennekens C . Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997; 336(14):973-9. DOI: 10.1056/NEJM199704033361401. View

18.

Tenaglia A, Buda A, WILKINS R, Barron M, Jeffords P, Vo K . Levels of expression of P-selectin, E-selectin, and intercellular adhesion molecule-1 in coronary atherectomy specimens from patients with stable and unstable angina pectoris. Am J Cardiol. 1997; 79(6):742-7. DOI: 10.1016/s0002-9149(96)00861-2. View

19.

Dansky H, Charlton S, Harper M, Smith J . T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A. 1997; 94(9):4642-6. PMC: 20777. DOI: 10.1073/pnas.94.9.4642. View

20.

Zahn S, Zwirner J, Spengler H, Gotze O . Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid. Eur J Immunol. 1997; 27(4):935-40. DOI: 10.1002/eji.1830270420. View