Effects of Sleep on Wake-induced C-fos Expression

Overview

Journal J Neurosci

Specialty Neurology

Date 1998 Jan 10

PMID 9391027

Citations 29

Authors

R Basheer

J E Sherin

C B Saper

J I Morgan

R W McCarley

P J Shiromani

Affiliations

Soon will be listed here.

Abstract

We investigated the effects of sleep on wake-induced c-fos expression in the cerebral cortex of rats and c-fos-lacZ transgenic mice. In the cortex of rats, the levels of c-Fos, detected both by immunocytochemistry and Western blot, remained high during 6 or 12 hr of enforced wakefulness but declined rapidly (within 1 hr) with increasing time of recovery sleep. Similarly, in the transgenic mice in which lacZ expression is driven from the c-fos promoter, beta-galactosidase activity was high after enforced wakefulness and declined with increasing amounts of sleep. These results suggest that the decrease in c-Fos protein in cortical neurons during sleep may be attributable to cessation of c-fos expression, activation of a process that degrades the wake-induced c-Fos, or both.

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