Diagnostic Dilemma in Pancreatic Lymphoma. Case Report and Review

Overview

Journal Int J Pancreatol

Specialty Gastroenterology

Date 1997 Aug 1

PMID 9387027

Citations 3

Authors

E Cario

M Runzi

K Metz

P Layer

H Goebell

Affiliations

Soon will be listed here.

Abstract

Non-Hodgkin's lymphoma predominantly involving the pancreas is a rare tumor of the gastrointestinal tract. Diagnosis can be difficult, since lymphoma may mimic carcinoma or pancreatitis. Lymphoproliferative diseases induced by immunosuppressive therapy frequently occur in the gastrointestinal tract of posttransplant patients. However, pancreatic involvement of posttransplant lymphoma is an exceptional condition. We present the case of a cyclosporin-treated renal transplant recipient with pancreatic lymphoma mimicking carcinomatous or inflammatory tumors. The diagnostic difficulties and treatment options of pancreatic lymphoma as well as lymphoproliferative disorders in immunosuppressed renal recipients are discussed in light of the current literature.

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Primary pancreatic lymphoma in Korea--a single center experience.

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References

Tikkakoski T, Siniluoto T, Paivansalo M, Typpo T, Turunen J, Apaja-Sarkkinen M . Diagnostic accuracy of ultrasound-guided fine-needle pancreatic biopsy. Rofo. 1992; 156(2):178-81. DOI: 10.1055/s-2008-1032860. View

Cockburn I . Assessment of the risks of malignancy and lymphomas developing in patients using Sandimmune. Transplant Proc. 1987; 19(1 Pt 2):1804-7. View

Baylor S, Berg J . Cross-classification and survival characteristics of 5,000 cases of cancer of the pancreas. J Surg Oncol. 1973; 5(4):335-58. DOI: 10.1002/jso.2930050410. View

Tuchek J, De Jong S, Pickleman J . Diagnosis, surgical intervention, and prognosis of primary pancreatic lymphoma. Am Surg. 1993; 59(8):513-8. View

Dinkel E, Helwig A, Jager B, Ruckauer K, Scholmerich J, Hauenstein K . [Computed tomographic-guided fine-needle biopsy of the pancreas for histology determination]. Radiologe. 1990; 30(9):420-4. View

Starzl T, Nalesnik M, Porter K, Ho M, Iwatsuki S, Griffith B . Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet. 1984; 1(8377):583-7. PMC: 2987704. DOI: 10.1016/s0140-6736(84)90994-2. View

Teefey S, Stephens D, Sheedy 2nd P . CT appearance of primary pancreatic lymphoma. Gastrointest Radiol. 1986; 11(1):41-3. DOI: 10.1007/BF02035029. View

Webb T, Lillemoe K, Pitt H, Jones R, Cameron J . Pancreatic lymphoma. Is surgery mandatory for diagnosis or treatment?. Ann Surg. 1989; 209(1):25-30. PMC: 1493876. DOI: 10.1097/00000658-198901000-00003. View

Penn I . Malignant lymphomas in organ transplant recipients. Transplant Proc. 1981; 13(1 Pt 2):736-8. View

10.

Rodriguez J, Kasberg C, Nipper M, Schoolar J, Riggs M, Dyck W . CT-guided needle biopsy of the pancreas: a retrospective analysis of diagnostic accuracy. Am J Gastroenterol. 1992; 87(11):1610-3. View

11.

Penn I, Starzl T . Malignant tumors arising de novo in immunosuppressed organ transplant recipients. Transplantation. 1972; 14(4):407-17. PMC: 3006181. DOI: 10.1097/00007890-197210000-00001. View

12.

Pasanen P, Eskelinen M, Vornanen M, Partanen K . Pancreatic lymphoma. Ann Chir Gynaecol. 1993; 82(3):207-9. View

13.

Palazzo L, Roseau G, Gayet B, Vilgrain V, Belghiti J, Fekete F . Endoscopic ultrasonography in the diagnosis and staging of pancreatic adenocarcinoma. Results of a prospective study with comparison to ultrasonography and CT scan. Endoscopy. 1993; 25(2):143-50. DOI: 10.1055/s-2007-1010273. View

14.

Prayer L, Schurawitzki H, Mallek R, Mostbeck G . CT in pancreatic involvement of non-Hodgkin lymphoma. Acta Radiol. 1992; 33(2):123-7. View

15.

Hu E, Horning S, Flynn S, Brown S, Warnke R, Sklar J . Diagnosis of B cell lymphoma by analysis of immunoglobulin gene rearrangements in biopsy specimens obtained by fine needle aspiration. J Clin Oncol. 1986; 4(3):278-83. DOI: 10.1200/JCO.1986.4.3.278. View

16.

Hart M, White T, BROWN P, Freeny P . Potentially curable masses in the pancreas. Am J Surg. 1987; 154(1):134-6. DOI: 10.1016/0002-9610(87)90303-5. View

17.

FISCHER M, KABAKOW B . Lymphoma of the pancreas. Mt Sinai J Med. 1987; 54(5):423-6. View

18.

Borrowdale R, Strong R . Primary lymphoma of the pancreas. Aust N Z J Surg. 1994; 64(6):444-6. DOI: 10.1111/j.1445-2197.1994.tb02250.x. View

19.

Shtamler B, Bickel A, Manor E, Ben Shahar M, Kuten A, SUPRUN H . Primary lymphoma of the head of the pancreas. J Surg Oncol. 1988; 38(1):48-51. DOI: 10.1002/jso.2930380113. View

20.

ACKERMAN N, AUST J, Bredenberg C, Hanson Jr V, ROGERS L . Problems in differentiating between pancreatic lymphoma and anaplastic carcinoma and their management. Ann Surg. 1976; 184(6):705-8. PMC: 1345411. DOI: 10.1097/00000658-197612000-00007. View