Insulin-like Actions of Nickel and Other Transition-metal Ions in Rat Fat-cells

Overview

Journal Biochem J

Specialty Biochemistry

Date 1976 Feb 15

PMID 938454

Citations 13

Authors

E D Saggerson

S R Sooranna

C J Evans

Affiliations

Soon will be listed here.

Abstract

NiC12 (1-6mM) decreased adrenaline and glucagon-stimulated lipolysis in rat fat-cells, and also considerably stimulated [U-14C]glucose incorporation into fat-cell lipids. 2. These insulin-like effects were also observed with CuCl, CuCl2, CoCl2 and (to a lesser extent) with MnCl2. 3. NiCl2 was less effective in mimicking insulin effects on [U-14C]fructose metabolism than on glucose utilization. 4. It is tentatively suggested that these transition-metal ions may mimic actions of insulin at the fat-cell plasma membrane which decrease lipolysis and stimulate glucose transport, but do not mimic certain other effects of the hormone on intracellular metabolic processes. 5. These results are discussed with reference to suggestions that redistributions of cellular Ca2+ are associated with insulin action in fat-cells.

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