The Herpes Simplex Virus Virulence Factor ICP34.5 and the Cellular Protein MyD116 Complex with Proliferating Cell Nuclear Antigen Through the 63-amino-acid Domain Conserved in ICP34.5, MyD116, and GADD34

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1997 Nov 26

PMID 9371605

Citations 35

Authors

S M Brown

A R MacLean

E A McKie

J Harland

Affiliations

Soon will be listed here.

Abstract

The herpes simplex virus (HSV) virulence factor ICP34.5, the mouse myeloid differentiation protein MyD116, and the hamster growth arrest and DNA damage protein GADD34 share a 63-amino-acid carboxyl domain which has significant homologies to otherwise divergent proteins. Here we report that both ICP34.5 and its cellular homolog MyD116 complex through the conserved domain with proliferating cell nuclear antigen. In addition, HSV infection induces a novel 70-kDa cellular protein detectable by antisera to both ICP34.5 and GADD34, demonstrating that this novel protein possesses homology with the 63-amino-acid conserved domain.

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