» Articles » PMID: 9351176

Reactivation of Epstein-Barr Virus: Regulation and Function of the BZLF1 Gene

Overview
Date 1997 Nov 14
PMID 9351176
Citations 122
Authors
Affiliations
Soon will be listed here.
Abstract

The switch from latent infection to virus replication in Epstein-Barr virus (EBV)-infected B cells is initiated by expression of the viral BZLF1 gene. Recent studies have identified the key cellular transcription factors involved in regulating this switch in viral programs and the signal transduction pathways to which they respond. Understanding this switch may facilitate development of strategies to interfere with EBV infection.

Citing Articles

Identifying the key regulators orchestrating Epstein-Barr virus reactivation.

Wang Y, Yu J, Pei Y Front Microbiol. 2024; 15:1505191.

PMID: 39703703 PMC: 11655498. DOI: 10.3389/fmicb.2024.1505191.


Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes .

SoRelle E, Reinoso-Vizcaino N, Horn G, Luftig M Front Immunol. 2022; 13:1001145.

PMID: 36248899 PMC: 9554744. DOI: 10.3389/fimmu.2022.1001145.


Maintenance of Epstein-Barr virus latency through interaction of LMP2A with CXCR4.

Qin N, Zhang Y, Xu L, Liu W, Luo B Arch Virol. 2022; 167(10):1947-1959.

PMID: 35752684 DOI: 10.1007/s00705-022-05511-w.


How Does Epstein-Barr Virus Interact With Other Microbiomes in EBV-Driven Cancers?.

Wen Y, Xu H, Han J, Jin R, Chen H Front Cell Infect Microbiol. 2022; 12:852066.

PMID: 35281433 PMC: 8904896. DOI: 10.3389/fcimb.2022.852066.


Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments.

Yiu S, Guo R, Zerbe C, Weekes M, Gewurz B Cell Rep. 2022; 38(10):110411.

PMID: 35263599 PMC: 8981113. DOI: 10.1016/j.celrep.2022.110411.