Pharmacokinetics of Lidocaine After Prolonged Intravenous Infusions in Uncomplicated Myocardial Infarction

Overview

Journal Ann Intern Med

Specialty General Medicine

Date 1977 Dec 1

PMID 931206

Citations 34

Authors

J LeLorier

D Grenon

Y Latour

G Caille

G Dumont

A Brosseau

A Solignac

Affiliations

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Abstract

The kinetics of the elimination of lidocaine upon discontinuation of lidocaine infusions lasting more than 24 h were studied in 12 patients with uncomplicated myocardial infarctions. In this group of patients the mean half-life of the elimination phase was found to be 3.22 h. This is significantly different from the half-life of 100 min that has been reported after bolus injections or infusions lasting less than 12 h. This longer half-life should be taken into consideration in estimating the duration of toxicity and the rate of administration of the drug during and after intravenous infusions lasting 24 h or more.

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