Nematophin, a Novel Antimicrobial Substance Produced by Xenorhabdus Nematophilus (Enterobactereaceae)

Overview

Journal Can J Microbiol

Specialty Microbiology

Date 1997 Aug 1

PMID 9304787

Citations 29

Authors

J Li

G Chen

J M Webster

Affiliations

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Abstract

A new antibiotic, nematophin, was isolated from strain BC1 of Xenorhabdus nematophilus and detected in all strains of X. nematophilus studied. Its structure is fully established as 3-indoleethyl (3'-methyl-2'-oxo)pentanamide by extensive spectroscopic study. The production of nematophin is affected by the strain type and culture conditions. The compound shows strong in vitro bioactivity against a series of fungal and bacterial species.

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