Immunodetection of Androgen Receptor in Human Urinary Bladder Cancer

Overview

Journal Histopathology

Specialties Anatomy & Histology
Pathology

Date 1997 Jun 1

PMID 9205860

Citations 24

Authors

Y H Zhuang

M Blauer

T Tammela

P Tuohimaa

Affiliations

Soon will be listed here.

Abstract

We investigated the expression of androgen receptor (AR) protein in transitional cell carcinoma of human urinary bladder in paraffin-embedded sections of tumours obtained from nine patients with urinary bladder cancer treated by radical cystectomy. In addition, immunoblotting of AR was also performed on selected samples. Nuclear immunoreactivity of AR was found in seven of the nine urinary bladder cancers studied. AR showed variable staining intensity within a tumour. In the immunoblots, a 110 kDa AR signal was seen with anti-AR antibody, and faint bands of 90 and 60 kDa were also observed. Immunohistochemistry of p53 and c-erbB-2 was also carried out and compared with the distribution of AR. The high frequency of AR expression suggests a role for androgens in transitional cell carcinoma of human urinary bladder.

Citing Articles

Roles of Androgen Receptor Signaling in Urothelial Carcinoma.

Sundi D, Collier K, Yang Y, Diaz D, Pohar K, Singer E Cancers (Basel). 2024; 16(4).

PMID: 38398136 PMC: 10886823. DOI: 10.3390/cancers16040746.

Histone Demethylase LSD1 Regulates Kidney Cancer Progression by Modulating Androgen Receptor Activity.

Lee K, Kim B, Jeong S, Jeong C, Ku J, Kwak C Int J Mol Sci. 2020; 21(17).

PMID: 32847068 PMC: 7503698. DOI: 10.3390/ijms21176089.

Histone Demethylase KDM7A Regulates Androgen Receptor Activity, and Its Chemical Inhibitor TC-E 5002 Overcomes Cisplatin-Resistance in Bladder Cancer Cells.

Lee K, Kim B, Jeong S, Jeong C, Ku J, Kim H Int J Mol Sci. 2020; 21(16).

PMID: 32781788 PMC: 7460860. DOI: 10.3390/ijms21165658.

The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis.

Ide H, Miyamoto H Cancers (Basel). 2020; 12(8).

PMID: 32759680 PMC: 7465876. DOI: 10.3390/cancers12082155.

Androgen receptor antagonist bicalutamide induces autophagy and apoptosis via ULK2 upregulation in human bladder cancer cells.

Hao K, Zhao S, Cui D, Zhang Y, Jiang C, Jing Y Int J Clin Exp Pathol. 2020; 10(7):7603-7615.

PMID: 31966605 PMC: 6965281.