Androgen Receptor Signaling in Bladder Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2017 Mar 1

PMID 28241422

Citations 44

Authors

Peng Li

Jinbo Chen

Hiroshi Miyamoto

Affiliations

Soon will be listed here.

Abstract

Emerging preclinical findings have indicated that steroid hormone receptor signaling plays an important role in bladder cancer outgrowth. In particular, androgen-mediated androgen receptor signals have been shown to correlate with the promotion of tumor development and progression, which may clearly explain some sex-specific differences in bladder cancer. This review summarizes and discusses the available data, suggesting the involvement of androgens and/or the androgen receptor pathways in urothelial carcinogenesis as well as tumor growth. While the precise mechanisms of the functions of the androgen receptor in urothelial cells remain far from being fully understood, current evidence may offer chemopreventive or therapeutic options, using androgen deprivation therapy, in patients with bladder cancer.

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