The Shiverer Mutation Affects the Persistence of Theiler's Virus in the Central Nervous System

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1997 Jul 1

PMID 9188567

Citations 10

Authors

F Bihl

C Pena-Rossi

J L Guenet

M Brahic

J F Bureau

Affiliations

Soon will be listed here.

Abstract

Theiler's virus persists in the white matter of the spinal cord of genetically susceptible mice and causes primary demyelination. The virus persists in macrophages/microglial cells, but also in oligodendrocytes, the myelin-forming cells. Susceptibility/resistance to this chronic infection has been mapped to several loci including one tentatively located in the telomeric region of chromosome 18, close to the myelin basic protein locus (Mbp locus). To determine if the MBP gene influences viral persistence, we inoculated C3H mice bearing the shiverer mutation, a 20-kb deletion in the gene. Whereas control C3H mice were of intermediate susceptibility, C3H mice heterozygous for the mutation were very susceptible, and those homozygous for the mutation were completely resistant. This resistance was not immune mediated. Furthermore, C3H/101H mice homozygous for a point mutation in the gene coding for the proteolipid protein of myelin, the rumpshaker mutation, were resistant. These results strongly support the view that oligodendrocytes are a necessary viral target for the establishment of a persistent infection by Theiler's virus.

Citing Articles

Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

Benner B, Martorell A, Mahadevan P, Najm F, Tesar P, Freundt E J Neurovirol. 2015; 22(3):336-48.

PMID: 26631080 DOI: 10.1007/s13365-015-0402-7.

Axon-myelin interactions during a viral infection of the central nervous system.

Brahic M, Roussarie J PLoS Pathog. 2009; 5(9):e1000519.

PMID: 19779566 PMC: 2743189. DOI: 10.1371/journal.ppat.1000519.

Axon myelin transfer of a non-enveloped virus.

Roussarie J, Ruffie C, Edgar J, Griffiths I, Brahic M PLoS One. 2007; 2(12):e1331.

PMID: 18159229 PMC: 2137932. DOI: 10.1371/journal.pone.0001331.

The role of myelin in Theiler's virus persistence in the central nervous system.

Roussarie J, Ruffie C, Brahic M PLoS Pathog. 2007; 3(2):e23.

PMID: 17305428 PMC: 1797621. DOI: 10.1371/journal.ppat.0030023.

Theiler's virus infection: a model for multiple sclerosis.

Oleszak E, Chang J, Friedman H, Katsetos C, Platsoucas C Clin Microbiol Rev. 2004; 17(1):174-207.

PMID: 14726460 PMC: 321460. DOI: 10.1128/CMR.17.1.174-207.2004.

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