Synthesis and Biological Activities of Higher Homologues of Retinoic Acid

Overview

Journal Farmaco

Publisher Elsevier

Specialties Chemistry
Pharmacology

Date 1997 Jan 1

PMID 9181680

Citations 5

Authors

J Y Winum

M Kamal

H Defacque

T Commes

C Chavis

M Lucas

J Marti

J L Montero

Affiliations

Soon will be listed here.

Abstract

Homoretinoic and bishomoretinoic acid have been synthesized. Fast reaction under ultrasonic activation (Wolff rearrangement, saponification) produced compounds in high yields. Only the bishomo analogue exhibits a significative activity alone and a synergistic effect with vitamin D3 on the differentiation of U937 leukemic cell line.

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