Thymus Dependence of the IgG Response: Role of T Cells is Restricted to Non-specific Rather Than Antigen-specific Factors

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1979 Jul 1

PMID 91574

Authors

J T Kemshead

B A Askonas

Affiliations

Soon will be listed here.

Abstract

We have been studying the requirement for T cells in the proliferation and maturation of partially differentiated memory cells into IgG antibody secreting cells. The role of T cells in such a system can be replaced by non-antigen-specific T-cell factor(s) present in the supernatant of a 24 h mixed lymphocyte reaction (TRF) but not by antigen-specific factors released upon in vitro induction of T-helper cells with antigen. A combination of antigen-specific and non-specific factors showed no evidence of synergy between the two sets of factors and we therefore conclude that the antigen-specific factors tested play no role in the later stages of B-memory cell maturation to IgG-antibody secreting cells.

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