Metabolic Changes in Occipital Lobe Epilepsy with Automatisms

Overview

Journal Front Neurol

Specialty Neurology

Date 2014 Aug 8

PMID 25101053

Citations 2

Authors

Chong H Wong

Armin Mohamed

Lingfeng Wen

Stefan Eberl

Ernest Somerville

Michael Fulham

Andrew F Bleasel

Affiliations

Soon will be listed here.

Abstract

Purpose: Some studies suggest that the pattern of glucose hypometabolism relates not only to the ictal-onset zone but also reflects seizure propagation. We investigated metabolic changes in patients with occipital lobe epilepsy (OLE) that may reflect propagation of ictal discharge during seizures with automatisms.

Methods: Fifteen patients who had undergone epilepsy surgery for intractable OLE and had undergone interictal Fluorine-18-fluorodeoxyglucose positron-emission tomography ((18)F-FDG-PET) between 1994 and 2004 were divided into two groups (with and without automatisms during seizure). Significant regions of hypometabolism were identified by comparing (18)F-FDG-PET results from each group with 16 healthy controls by using statistical parametric mapping.

Key Findings: Significant hypometabolism was confined largely to the epileptogenic occipital lobe in the patient group without automatisms. In patients with automatisms, glucose hypometabolism extended from the epileptogenic occipital lobe into the ipsilateral temporal lobe.

Significance: We identified a distinctive hypometabolic pattern that was specific for OLE patients with automatisms during a seizure. This finding supports the postulate that seizure propagation is a cause of glucose hypometabolism beyond the region of seizure onset.

Citing Articles

Resection of bilateral occipital lobe lesions during a single operation as a treatment for bilateral occipital lobe epilepsy.

Lyu Y, Xu X, Dai S, Feng M, Shen S, Zhang G World J Clin Cases. 2022; 9(34):10518-10529.

PMID: 35004983 PMC: 8686130. DOI: 10.12998/wjcc.v9.i34.10518.

The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection.

Latini F, Hjortberg M, Aldskogius H, Ryttlefors M Behav Neurol. 2015; 2015:872645.

PMID: 26063964 PMC: 4430656. DOI: 10.1155/2015/872645.

References

Luders H, Acharya J, Baumgartner C, Benbadis S, Bleasel A, Burgess R . Semiological seizure classification. Epilepsia. 1998; 39(9):1006-13. DOI: 10.1111/j.1528-1157.1998.tb01452.x. View

Catani M, Jones D, Donato R, Ffytche D . Occipito-temporal connections in the human brain. Brain. 2003; 126(Pt 9):2093-107. DOI: 10.1093/brain/awg203. View

Blume W, Luders H, Mizrahi E, Tassinari C, Boas W, Engel Jr J . Glossary of descriptive terminology for ictal semiology: report of the ILAE task force on classification and terminology. Epilepsia. 2001; 42(9):1212-8. DOI: 10.1046/j.1528-1157.2001.22001.x. View

Collins R, Caston T . Functional anatomy of occipital lobe seizures: an experimental study in rats. Neurology. 1979; 29(5):705-16. DOI: 10.1212/wnl.29.5.705. View

Usui N, Mihara T, Baba K, Matsuda K, Tottori T, Umeoka S . Early seizure propagation from the occipital lobe to medial temporal structures and its surgical implication. Epileptic Disord. 2008; 10(4):260-5. DOI: 10.1684/epd.2008.0223. View

Dupont S, Semah F, Baulac M, Samson Y . The underlying pathophysiology of ictal dystonia in temporal lobe epilepsy: an FDG-PET study. Neurology. 1998; 51(5):1289-92. DOI: 10.1212/wnl.51.5.1289. View

Chassoux F, Semah F, Bouilleret V, Landre E, Devaux B, Turak B . Metabolic changes and electro-clinical patterns in mesio-temporal lobe epilepsy: a correlative study. Brain. 2003; 127(Pt 1):164-74. DOI: 10.1093/brain/awh014. View

Turner B, Mishkin M, Knapp M . Organization of the amygdalopetal projections from modality-specific cortical association areas in the monkey. J Comp Neurol. 1980; 191(4):515-43. DOI: 10.1002/cne.901910402. View

JASPER H . SOME PHYSIOLOGICAL MECHANISMS INVOLVED IN EPILEPTIC AUTOMATISMS. Epilepsia. 1964; 5:1-20. DOI: 10.1111/j.1528-1157.1964.tb04341.x. View

10.

Williamson P, Thadani V, Darcey T, Spencer D, Spencer S, Mattson R . Occipital lobe epilepsy: clinical characteristics, seizure spread patterns, and results of surgery. Ann Neurol. 1992; 31(1):3-13. DOI: 10.1002/ana.410310103. View

11.

Kim S, Lee D, Lee S, Kim Y, Kang K, Chung C . Diagnostic performance of [18F]FDG-PET and ictal [99mTc]-HMPAO SPECT in occipital lobe epilepsy. Epilepsia. 2002; 42(12):1531-40. DOI: 10.1046/j.1528-1157.2001.21901.x. View

12.

Savic I, Altshuler L, Baxter L, Engel Jr J . Pattern of interictal hypometabolism in PET scans with fludeoxyglucose F 18 reflects prior seizure types in patients with mesial temporal lobe seizures. Arch Neurol. 1997; 54(2):129-36. DOI: 10.1001/archneur.1997.00550140011006. View

13.

Eberl S, Anayat A, Fulton R, Hooper P, Fulham M . Evaluation of two population-based input functions for quantitative neurological FDG PET studies. Eur J Nucl Med. 1997; 24(3):299-304. DOI: 10.1007/BF01728767. View

14.

Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N . Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002; 15(1):273-89. DOI: 10.1006/nimg.2001.0978. View

15.

TALAIRACH J, BANCAUD J, Geier S, BONIS A, SZIKLA G, Rusu M . The cingulate gyrus and human behaviour. Electroencephalogr Clin Neurophysiol. 1973; 34(1):45-52. DOI: 10.1016/0013-4694(73)90149-1. View

16.

Wong C, Bleasel A, Wen L, Eberl S, Byth K, Fulham M . Relationship between preoperative hypometabolism and surgical outcome in neocortical epilepsy surgery. Epilepsia. 2012; 53(8):1333-40. DOI: 10.1111/j.1528-1167.2012.03547.x. View

17.

Wong C, Bleasel A, Wen L, Eberl S, Byth K, Fulham M . The topography and significance of extratemporal hypometabolism in refractory mesial temporal lobe epilepsy examined by FDG-PET. Epilepsia. 2010; 51(8):1365-73. DOI: 10.1111/j.1528-1167.2010.02552.x. View

18.

Sturm J, Newton M, Chinvarun Y, Berlangieri S, Berkovic S . Ictal SPECT and interictal PET in the localization of occipital lobe epilepsy. Epilepsia. 2000; 41(4):463-6. DOI: 10.1111/j.1528-1157.2000.tb00190.x. View

19.

Rusu V, Chassoux F, Landre E, Bouilleret V, Nataf F, Devaux B . Dystonic posturing in seizures of mesial temporal origin: electroclinical and metabolic patterns. Neurology. 2005; 65(10):1612-9. DOI: 10.1212/01.wnl.0000184510.44808.50. View

20.

Salanova V, Andermann F, Olivier A, Rasmussen T, Quesney L . Occipital lobe epilepsy: electroclinical manifestations, electrocorticography, cortical stimulation and outcome in 42 patients treated between 1930 and 1991. Surgery of occipital lobe epilepsy. Brain. 1992; 115 ( Pt 6):1655-80. DOI: 10.1093/brain/115.6.1655. View