Two Limonoids from Turraea Obtusifolia (Meliaceae), Prieurianin and Rohitukin, Antagonise 20-hydroxyecdysone Action in a Drosophila Cell Line
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Bioassay-assisted HPLC analyses yielded two prieurianin-type limonoids, prieurianin and rohitukin, from the seeds of Turraea obtusifolia, which act as antagonists of 20-hydroxyecdysone action in the Drosophila melanogaster BII cell line. With a 20-hydroxyecdysone concentration of 5 x 10(-8) M, the ED50 values for prieurianin and rohitukin are 10(-5) M and 1.25 x 10(-4) M, respectively.
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