Nitrogen-containing Dimeric Nor-multiflorane Triterpene from a Turraea Sp

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2014 Apr 30

PMID 24773558

Citations 3

Authors

Vincent E Rasamison

L Harinantenaina Rakotondraibe

Carla Slebodnick

Peggy J Brodie

Michel Ratsimbason

Karen TenDyke

Yongchun Shen

Lucien M Randrianjanaka

David G I Kingston

Affiliations

Soon will be listed here.

Abstract

The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.

Citing Articles

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents.

Soica C, Voicu M, Ghiulai R, Dehelean C, Racoviceanu R, Trandafirescu C Front Endocrinol (Lausanne). 2021; 11:612396.

PMID: 33552000 PMC: 7859451. DOI: 10.3389/fendo.2020.612396.

Neolignans and other metabolites from Ocotea cymosa from the Madagascar rain forest and their biological activities.

Rakotondraibe L, Graupner P, Xiong Q, Olson M, Wiley J, Krai P J Nat Prod. 2015; 78(3):431-40.

PMID: 25650896 PMC: 4410025. DOI: 10.1021/np5008153.

Antiproliferative and antimalarial sesquiterpene lactones from Piptocoma antillana from Puerto Rico.

Liu Y, Rakotondraibea L, Brodie P, Wiley J, Cassera M, Goetzc M Nat Prod Commun. 2014; 9(10):1403-6.

PMID: 25522525 PMC: 4311553.

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