Transcription Factors Vs Nucleosomes: Regulation of the PHO5 Promoter in Yeast

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1997 Mar 1

PMID 9066259

Citations 79

Authors

J Svaren

W Horz

Affiliations

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Abstract

Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The chromatin transition requires a DNA-binding protein, Pho4, and its transactivation domain. The mechanism of nucleosome disruption and the contribution of the nucleosomes to PHO5 regulation are reviewed.

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